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    Recent progress and applications in glycosaminoglycan and heparin research

    Author
    Laremore, Tatiana N.; Zhang, Fuming; Dordick, Jonathan S.; Liu, Jian; Linhardt, Robert J.
    ORCID
    https://orcid.org/0000-0003-2219-5833
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    RECENT PROGRESS AND APPLICATIONS IN GLYCOSAMINOGLYCAN AND.pdf (1.706Mb)
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    Date Issued
    2009-12-01
    Subject
    Biology; Chemistry and chemical biology; Chemical and biological engineering; Biomedical engineering
    Degree
    Terms of Use
    In Copyright : this Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). https://rightsstatements.org/page/InC/1.0/;
    Full Citation
    Recent progress and applications in glycosaminoglycan and heparin research, T. N. Laremore, F. Zhang, J. S. Dordick, J. Liu, R. J. Linhardt, Current Opinions in Chemical Biology, 13, 633–640, 2009.
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    URI
    https://hdl.handle.net/20.500.13015/5262; https://doi.org/10.1016/j.cbpa.2009.08.017
    Abstract
    Heparin, the focus of this review, is a critically important anticoagulant drug produced from animal sources, which was contaminated last year leading to a number of adverse side effects, some resulting in death. Heparin is a highly acidic polysaccharide and a member of a family of biopolymers called glycosaminoglycans. The structure and activities of heparin are detailed along with recent advances in heparin structural analysis and biological evaluation. Current state-of-the-art chemical and chemoenzymatic synthesis of heparin and new approaches for its metabolic engineering are described. New technologies, including microarrays and digital microfluidics, are proposed for high-throughput synthesis and screening of heparin and for the fabrication of an artificial Golgi.;
    Description
    Current Opinions in Chemical Biology, 13, 633–640; Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
    Department
    The Linhardt Research Labs.; The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS);
    Publisher
    Elsevier
    Relationships
    The Linhardt Research Labs Online Collection; Rensselaer Polytechnic Institute, Troy, NY; Current Opinion in Chemical Biology; https://harc.rpi.edu/;
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    A full text version is available in DSpace@RPI;
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