Negative electron transfer dissociation Fourier transform mass spectrometry of glycosaminoglycan carbohydrates
Authors
Leach, Franklin E.
Wolff, Jeremy J.
Xiao, Zhongping
Ly, Mellisa
Laremore, Tatiana N.
Arungundram, Sailaja
Al-Mafraji, Kanar
Venot, Andre
Boons, Geert Jan
Linhardt, Robert J.
ORCID
https://orcid.org/0000-0003-2219-5833
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Other Contributors
Issue Date
2011-01-01
Keywords
Biology , Chemistry and chemical biology , Chemical and biological engineering , Biomedical engineering
Degree
Terms of Use
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Full Citation
Negative electron transfer dissociation Fourier transform mass spectrometry of glycosaminoglycan carbohydrates, F. E. Leach, J. J. Wolff, Z. Xiao, M. Ly, T. N. Laremore, S. Arungundram, K. Al-Mafraji, A. Venot, G.-J. Boons, R. J. Linhardt, I. Jonathan Amster, European Journal of Mass Spectrometry, 71, 167-176, 2011.
Abstract
Electron transfer through gas-phase ion–ion reactions has led to the widespread application ofelectron-based techniques once only capable in ion trapping mass spectrometers. Although anymass analyzer can, in theory, be coupled to an ion–ion reaction device (typically a 3-D ion trap),some systems of interest exceed the capabilities of most mass spectrometers. This case isparticularly true in the structural characterization of glycosaminoglycan (GAG) oligosaccharides.To adequately characterize highly sulfated GAGs or oligosac charides above the tetrasaccharidelevel, a high-resolution mass analyzer is required. To extend previous efforts on an ion trap massspectrometer, negative electron transfer dissociation coupled with a Fourier transform ioncyclotron resonance mass spectrometer has been applied to increasingly sulfated heparan sulfateand heparin tetrasaccharides as well as a dermatan sulfate octasaccharide. Results similar to thoseobtained by electron detachment dissociation are observed.
Description
European Journal of Mass Spectrometry, 71, 167-176
Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
Department
The Linhardt Research Labs.
The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)
The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)
Publisher
Sage
Relationships
The Linhardt Research Labs Online Collection
Rensselaer Polytechnic Institute, Troy, NY
European Journal of Mass Spectrometry
https://harc.rpi.edu/
Rensselaer Polytechnic Institute, Troy, NY
European Journal of Mass Spectrometry
https://harc.rpi.edu/
Access
A full text version is available in DSpace@RPI