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    Electrophoresis for the analysis of heparin purity and quality

    Author
    Volpi, Nicola; Maccari, Francesca; Suwan, Jiraporn; Linhardt, Robert J.
    ORCID
    https://orcid.org/0000-0003-2219-5833
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    ELECTROPHORESIS FOR THE ANALYSIS OF HEPARIN PURITY AND QUALITY.pdf (2.716Mb)
    Other Contributors
    Date Issued
    2012-06-01
    Subject
    Biology; Chemistry and chemical biology; Chemical and biological engineering; Biomedical engineering
    Degree
    Terms of Use
    In Copyright : this Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). https://rightsstatements.org/page/InC/1.0/;
    Full Citation
    Electrophoresis for the analysis of heparin purity and quality, N. Volpi, F. Maccari, R. J. Linhardt, Electrophoresis, 33, 1531-1537, 2012.
    Metadata
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    URI
    https://hdl.handle.net/20.500.13015/5311; https://doi.org/10.1002/elps.201100479
    Abstract
    The adulteration of raw heparin with oversulfated chondroitin sulfate (OSCS) in 2007–2008 produced a global crisis resulting in extensive revisions to the pharmacopeia monographs and prompting the FDA to recommend the development of additional methods for the analysis of heparin purity. As a consequence, a wide variety of innovative analytical approaches have been developed for the quality assurance and purity of unfractionated and low-molecular-weight heparins. This review discusses recent developments in electrophoresis techniques available for the sensitive separation, detection, and partial structural characterization of heparin contaminants. In particular, this review summarizes recent publications on heparin quality and related impurity analysis using electrophoretic separations such as capillary electrophoresis (CE) of intact polysaccharides and hexosamines derived from their acidic hydrolysis, and polyacrylamide gel electrophoresis (PAGE) for the separation of heparin samples without and in the presence of its relatively specific depolymerization process with nitrous acid treatment.;
    Description
    Electrophoresis, 33, 1531-1537; Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
    Department
    The Linhardt Research Labs.; The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS);
    Publisher
    Wiley
    Relationships
    The Linhardt Research Labs Online Collection; Rensselaer Polytechnic Institute, Troy, NY; Electrophoresis; https://harc.rpi.edu/;
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    A full text version is available in DSpace@RPI;
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