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    Heparinoids activate a tumor-secreted protease via tethering and V-type allostery

    Author
    Fulcher, Y.G.; Gari, R.R.S.; Frey, N.C.; Zhang, F.; Linhardt, Robert J.; King, G.M.; Van Doren, S.R.
    ORCID
    https://orcid.org/0000-0003-2219-5833
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    HEPARINOIDS ACTIVATE A PROTEASE, SECRETED BY MUCOSA AND.pdf (2.153Mb)
    Other Contributors
    Date Issued
    2014
    Subject
    Biology; Chemistry and chemical biology; Chemical and biological engineering; Biomedical engineering
    Degree
    Terms of Use
    In Copyright : this Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). https://rightsstatements.org/page/InC/1.0/;
    Full Citation
    Heparinoids activate a tumor-secreted protease via tethering and V-type allostery, Y. G. Fulcher, R.R.S. Gari, N.C. Frey, F. Zhang, R.J. Linhardt, G.M. King, S.R. Van Doren, ACS Chemical Biology, 9, 957−966, 2014.
    Metadata
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    URI
    https://hdl.handle.net/20.500.13015/5324; https://doi.org/10.1021/cb400898t
    Abstract
    The chemoenzymatic synthesis of heparan sulfate tetrasaccharide (1) and hexasaccharide (2) with a fluorous tag attached at the reducing end is reported. The fluorous tert-butyl dicarbonate (FBoc) tag did not interfere with enzymatic recognition for both elongation and specific sulfation, and flash purification was performed by standard fluorous solid-phase extraction (FSPE). Based on an FBoc attached disaccharide as acceptor, a series of partial N-sulfated, 6-O-sulfated heparan sulfate oligosaccharides were successfully synthesized employing fluorous techniques.;
    Description
    ACS Chemical Biology, 9, 957−966; Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
    Department
    The Linhardt Research Labs.; The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS);
    Publisher
    American Chemical Society (ACS)
    Relationships
    The Linhardt Research Labs Online Collection; Rensselaer Polytechnic Institute, Troy, NY; https://harc.rpi.edu/;
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    A full text version is available in DSpace@RPI;
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