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    Design of homogeneous and reversible low molecular weight heparins

    Author
    Xu, Y.; Cai, C.; Chandarajoti, K.; Hsieh, P.-H.; Li, L.; Pham, T.Q.; Sparkenbaugh, E.M.; Sheng, J.; Key, N.S.; Pawlinski, R.; Harris, E.N.; Linhardt, Robert J.; Liu, Jian
    ORCID
    https://orcid.org/0000-0003-2219-5833
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    HOMOGENEOUS LOW-MOLECULAR-WEIGHT HEPARINS WITH REVERSIBLE.pdf (203.3Kb)
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    Date Issued
    2014
    Subject
    Biology; Chemistry and chemical biology; Chemical and biological engineering; Biomedical engineering
    Degree
    Terms of Use
    In Copyright : this Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). https://rightsstatements.org/page/InC/1.0/;
    Full Citation
    Design of homogeneous and reversible low molecular weight heparins, Y. Xu, C. Cai, K. Chandarajoti, P.-H. Hsieh, L.Li, T. Q. Pham, E. M. Sparkenbaugh, J. Sheng, N. S. Key, R. Pawlinski, E. N. Harris, R.J. Linhardt, Jian Liu, Nature Chemical Biology, 10, 248-250, 2014.
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    URI
    https://hdl.handle.net/20.500.13015/5327; https://doi.org/10.1038%2Fnchembio.1459
    Abstract
    Low-molecular-weight heparins (LMWHs) are carbohydrate-based anticoagulants clinically used to treat thrombotic disorders, but impurities, structural heterogeneity or functional irreversibility can limit treatment options. We report a series of synthetic LMWHs prepared by cost-effective chemoenzymatic methods. The high activity of one defined synthetic LMWH against human factor Xa (FXa) was reversible in vitro and in vivo using protamine, demonstrating that synthetically accessible constructs can have a critical role in the next generation of LMWHs.;
    Description
    Nature Chemical Biology, 10, 248-250; Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
    Department
    The Linhardt Research Labs.; The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS);
    Publisher
    Nature
    Relationships
    The Linhardt Research Labs Online Collection; Rensselaer Polytechnic Institute, Troy, NY; https://harc.rpi.edu/;
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    A full text version is available in DSpace@RPI;
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