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dc.contributor.authorXu, Y.
dc.contributor.authorCai, C.
dc.contributor.authorChandarajoti, K.
dc.contributor.authorHsieh, P.-H.
dc.contributor.authorLi, L.
dc.contributor.authorPham, T.Q.
dc.contributor.authorSparkenbaugh, E.M.
dc.contributor.authorSheng, J.
dc.contributor.authorKey, N.S.
dc.contributor.authorPawlinski, R.
dc.contributor.authorHarris, E.N.
dc.contributor.authorLinhardt, Robert J.
dc.contributor.authorLiu, Jian
dc.date2014
dc.date.accessioned2022-06-23T04:17:32Z
dc.date.available2022-06-23T04:17:32Z
dc.date.issued2014
dc.identifier.citationDesign of homogeneous and reversible low molecular weight heparins, Y. Xu, C. Cai, K. Chandarajoti, P.-H. Hsieh, L.Li, T. Q. Pham, E. M. Sparkenbaugh, J. Sheng, N. S. Key, R. Pawlinski, E. N. Harris, R.J. Linhardt, Jian Liu, Nature Chemical Biology, 10, 248-250, 2014.
dc.identifier.urihttps://hdl.handle.net/20.500.13015/5327
dc.identifier.urihttps://doi.org/10.1038%2Fnchembio.1459
dc.descriptionNature Chemical Biology, 10, 248-250
dc.descriptionNote : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
dc.description.abstractLow-molecular-weight heparins (LMWHs) are carbohydrate-based anticoagulants clinically used to treat thrombotic disorders, but impurities, structural heterogeneity or functional irreversibility can limit treatment options. We report a series of synthetic LMWHs prepared by cost-effective chemoenzymatic methods. The high activity of one defined synthetic LMWH against human factor Xa (FXa) was reversible in vitro and in vivo using protamine, demonstrating that synthetically accessible constructs can have a critical role in the next generation of LMWHs.
dc.languageen_US
dc.language.isoENG
dc.publisherNature
dc.relation.ispartofThe Linhardt Research Labs Online Collection
dc.relation.ispartofRensselaer Polytechnic Institute, Troy, NY
dc.relation.urihttps://harc.rpi.edu/
dc.subjectBiology
dc.subjectChemistry and chemical biology
dc.subjectChemical and biological engineering
dc.subjectBiomedical engineering
dc.titleDesign of homogeneous and reversible low molecular weight heparins
dc.typeArticle
dcterms.accessRightsA full text version is available in DSpace@RPI
dcterms.isVersionOfhttps://doi.org/10.1038%2Fnchembio.1459
dc.rights.holderIn Copyright : this Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). https://rightsstatements.org/page/InC/1.0/
dc.creator.identifierhttps://orcid.org/0000-0003-2219-5833
dc.relation.departmentThe Linhardt Research Labs.
dc.relation.departmentThe Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)


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