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    Glycosaminoglycans in infectious disease

    Author
    Kamhi, E.; Joo, E.J.; Dordick, J.S.; Linhardt, Robert J.
    ORCID
    https://orcid.org/0000-0003-2219-5833
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    ROLE OF GLYCOSAMINOGLYCANS IN INFECTIOUS DISEASE.pdf (288.2Kb)
    Other Contributors
    Date Issued
    2013
    Subject
    Biology; Chemistry and chemical biology; Chemical and biological engineering; Biomedical engineering
    Degree
    Terms of Use
    In Copyright : this Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). https://rightsstatements.org/page/InC/1.0/;
    Full Citation
    Glycosaminoglycans in infectious disease, E. Kamhi, E. J. Joo, J. S. Dordick, R. J. Linhardt, Biological Reviews, 88, 928–943, 2013.
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    URI
    https://hdl.handle.net/20.500.13015/5336; https://doi.org/10.1111/brv.12034
    Abstract
    Glycosaminoglycans (GAGs) are complex carbohydrates that are ubiquitously present on the cell surface and in the extracellular matrix. Interactions between GAGs and pathogens represent the first line of contact between pathogen and host cell and are crucial to a pathogen's invasive potential. Their complexity and structural diversity allow GAGs to control a wide array of biological interactions influencing many physiological and pathological processes, including adhesion, cell-to-cell communication, biochemical cascades, and the immune response. In recent years, increasing evidence indicates an extraordinary role for GAGs in the pathogenesis of viruses, bacteria and parasites. Herein, we examine the interface between GAGs and different pathogens, and address the divergent biological functions of GAGs in infectious disease. We consider approaches to use this understanding to design novel therapeutic strategies addressing new challenges in the treatment of infectious diseases.;
    Description
    Biological Reviews, 88, 928–943; Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
    Department
    The Linhardt Research Labs.; The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS);
    Publisher
    Wiley
    Relationships
    The Linhardt Research Labs Online Collection; Rensselaer Polytechnic Institute, Troy, NY; https://harc.rpi.edu/;
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    A full text version is available in DSpace@RPI;
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