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dc.contributor.authorWeyers, Amanda
dc.contributor.authorYang, Bo
dc.contributor.authorPark, Jong Hwan
dc.contributor.authorKim, Yong Seok
dc.contributor.authorKim, Sun Moon
dc.contributor.authorLee, Sang Eok
dc.contributor.authorZhang, Fuming
dc.contributor.authorLee, Kyung Bok
dc.contributor.authorLinhardt, Robert J.
dc.date2013
dc.date.accessioned2022-06-23T04:17:35Z
dc.date.available2022-06-23T04:17:35Z
dc.date.issued2013-10-01
dc.identifier.citationMicroanalysis of stomach cancer glycosaminoglycans, A. Weyers, B. Yang, J.-H. Park, Y.-S. Kim, S.-M. Kim, S.-E. Lee, F. Zhang, K. B. Lee, R. J. Linhardt, Glycoconjugate Journal, 30, 701–707, 2013.
dc.identifier.issn15734986
dc.identifier.issn2820080
dc.identifier.urihttps://hdl.handle.net/20.500.13015/5338
dc.identifier.urihttps://doi.org/10.1007/s10719-013-9476-8
dc.descriptionGlycoconjugate Journal, 30, 701–707
dc.descriptionNote : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
dc.description.abstractGlycosaminoglycans (GAGS) are anionic, linear, polysaccharides involved in cell signaling. The GAG content, composition and structure of human tissue have been suggested to play a role in cancer and might provide useful diagnostic or prognostic markers. The current study examines 17 stomach tissue biopsy samples taken from normal individuals and from patients with gastric cancers. An ultrasensitive liquid chromatography (LC) - mass spectrometry assay was applied to individual biopsy samples as small 250 μg providing GAG content and disaccharide composition. The results of these analyses show a significant increase in non-sulfated chondroitin/dermatan sulfate concentration in all cancer samples when compared to normal tissues. In addition in advanced gastric cancer, a significant decrease is observed in hyaluronan.
dc.description.sponsorshipNational Institutes of Health
dc.languageen_US
dc.language.isoENG
dc.publisherSpringer
dc.relation.ispartofThe Linhardt Research Labs Online Collection
dc.relation.ispartofRensselaer Polytechnic Institute, Troy, NY
dc.relation.ispartofGlycoconjugate Journal
dc.relation.urihttps://harc.rpi.edu/
dc.subjectBiology
dc.subjectChemistry and chemical biology
dc.subjectChemical and biological engineering
dc.subjectBiomedical engineering
dc.titleMicroanalysis of stomach cancer glycosaminoglycans
dc.typeArticle
dcterms.accessRightsA full text version is available in DSpace@RPI
dcterms.isPartOfJournal
dcterms.isVersionOfhttps://doi.org/10.1007/s10719-013-9476-8
dc.rights.holderIn Copyright : this Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). https://rightsstatements.org/page/InC/1.0/
dc.creator.identifierhttps://orcid.org/0000-0003-2219-5833
dc.relation.departmentThe Linhardt Research Labs.
dc.relation.departmentThe Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)
rpi.description.pages701-707
rpi.description.volume30


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