| dc.contributor.author | Weyers, Amanda | |
| dc.contributor.author | Yang, Bo | |
| dc.contributor.author | Park, Jong Hwan | |
| dc.contributor.author | Kim, Yong Seok | |
| dc.contributor.author | Kim, Sun Moon | |
| dc.contributor.author | Lee, Sang Eok | |
| dc.contributor.author | Zhang, Fuming | |
| dc.contributor.author | Lee, Kyung Bok | |
| dc.contributor.author | Linhardt, Robert J. | |
| dc.date | 2013 | |
| dc.date.accessioned | 2022-06-23T04:17:35Z | |
| dc.date.available | 2022-06-23T04:17:35Z | |
| dc.date.issued | 2013-10-01 | |
| dc.identifier.citation | Microanalysis of stomach cancer glycosaminoglycans, A. Weyers, B. Yang, J.-H. Park, Y.-S. Kim, S.-M. Kim, S.-E. Lee, F. Zhang, K. B. Lee, R. J. Linhardt, Glycoconjugate Journal, 30, 701–707, 2013. | |
| dc.identifier.issn | 15734986 | |
| dc.identifier.issn | 2820080 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.13015/5338 | |
| dc.identifier.uri | https://doi.org/10.1007/s10719-013-9476-8 | |
| dc.description | Glycoconjugate Journal, 30, 701–707 | |
| dc.description | Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform. | |
| dc.description.abstract | Glycosaminoglycans (GAGS) are anionic, linear, polysaccharides involved in cell signaling. The GAG content, composition and structure of human tissue have been suggested to play a role in cancer and might provide useful diagnostic or prognostic markers. The current study examines 17 stomach tissue biopsy samples taken from normal individuals and from patients with gastric cancers. An ultrasensitive liquid chromatography (LC) - mass spectrometry assay was applied to individual biopsy samples as small 250 μg providing GAG content and disaccharide composition. The results of these analyses show a significant increase in non-sulfated chondroitin/dermatan sulfate concentration in all cancer samples when compared to normal tissues. In addition in advanced gastric cancer, a significant decrease is observed in hyaluronan. | |
| dc.description.sponsorship | National Institutes of Health | |
| dc.language | en_US | |
| dc.language.iso | ENG | |
| dc.publisher | Springer | |
| dc.relation.ispartof | The Linhardt Research Labs Online Collection | |
| dc.relation.ispartof | Rensselaer Polytechnic Institute, Troy, NY | |
| dc.relation.ispartof | Glycoconjugate Journal | |
| dc.relation.uri | https://harc.rpi.edu/ | |
| dc.subject | Biology | |
| dc.subject | Chemistry and chemical biology | |
| dc.subject | Chemical and biological engineering | |
| dc.subject | Biomedical engineering | |
| dc.title | Microanalysis of stomach cancer glycosaminoglycans | |
| dc.type | Article | |
| dcterms.accessRights | A full text version is available in DSpace@RPI | |
| dcterms.isPartOf | Journal | |
| dcterms.isVersionOf | https://doi.org/10.1007/s10719-013-9476-8 | |
| dc.rights.holder | In Copyright : this Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). https://rightsstatements.org/page/InC/1.0/ | |
| dc.creator.identifier | https://orcid.org/0000-0003-2219-5833 | |
| dc.relation.department | The Linhardt Research Labs. | |
| dc.relation.department | The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS) | |
| rpi.description.pages | 701-707 | |
| rpi.description.volume | 30 | |
