Author
Zhang, Xing; Khalidi, Omar; Kim, So Young; Wang, Ruitong; Schultz, Victor; Cress, Brady F.; Gross, Richard A.; Koffas, Mattheos A.G.; Linhardt, Robert J.
Other Contributors
Date Issued
2016-07-01
Subject
Biology; Chemistry and chemical biology; Chemical and biological engineering; Biomedical engineering
Degree
Terms of Use
In Copyright : this Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). https://rightsstatements.org/page/InC/1.0/;
Full Citation
Synthesis and biological evaluation of 5,7-dihydroxyflavanone derivatives as antimicrobial agents, X. Zhang, O. Khalidi, S.-Y. Kim, R. Wang, V. Schultz, B. F. Cress, R. A. Gross, M. A.G. Koffas, R. J. Linhardt, Bioorganic & Medicinal Chemistry Letters, 26, 3089–3092, 2016
Abstract
A series of 5,7-dihydroxyflavanone derivatives were efficiently synthesized. Their antimicrobial efficacy on Gram-negative, Gram-positive bacteria and yeast were evaluated. Among these compounds, most of the halogenated derivatives exhibited the best antimicrobial activity against Gram-positive bacteria, the yeast Saccharomyces cerevisiae, and the Gram-negative bacterium Vibrio cholerae. The cytotoxicities of these compounds were low as evaluated on HepG2 cells using a cell viability assay. This study suggests that halogenated flavanones might represent promising pharmacological candidates for further drug development.;
Description
Bioorganic & Medicinal Chemistry Letters, 26, 3089–3092; Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
Department
The Linhardt Research Labs.; The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS);
Publisher
Elsevier
Relationships
The Linhardt Research Labs Online Collection; Rensselaer Polytechnic Institute, Troy, NY; Bioorganic and Medicinal Chemistry Letters; https://harc.rpi.edu/;
Access
A full text version is available in DSpace@RPI;
