Biology; Chemistry and chemical biology; Chemical and biological engineering; Biomedical engineering
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Synthesis and biological evaluation of 5,7-dihydroxyflavanone derivatives as antimicrobial agents, X. Zhang, O. Khalidi, S.-Y. Kim, R. Wang, V. Schultz, B. F. Cress, R. A. Gross, M. A.G. Koffas, R. J. Linhardt, Bioorganic & Medicinal Chemistry Letters, 26, 3089–3092, 2016
A series of 5,7-dihydroxyflavanone derivatives were efficiently synthesized. Their antimicrobial efficacy on Gram-negative, Gram-positive bacteria and yeast were evaluated. Among these compounds, most of the halogenated derivatives exhibited the best antimicrobial activity against Gram-positive bacteria, the yeast Saccharomyces cerevisiae, and the Gram-negative bacterium Vibrio cholerae. The cytotoxicities of these compounds were low as evaluated on HepG2 cells using a cell viability assay. This study suggests that halogenated flavanones might represent promising pharmacological candidates for further drug development.;
Bioorganic & Medicinal Chemistry Letters, 26, 3089–3092; Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
The Linhardt Research Labs.; The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS);
The Linhardt Research Labs Online Collection; Rensselaer Polytechnic Institute, Troy, NY; Bioorganic and Medicinal Chemistry Letters; https://harc.rpi.edu/;