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    Chemoenzymatic synthesis of heparin

    Author
    Dickinson, D.M.; Liu, J.; Linhardt, Robert J.
    ORCID
    https://orcid.org/0000-0003-2219-5833
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    CHEMOENZYMATIC SYNTHESIS OF HEPARAN SULFATE AND HEPARIN.pdf (820.6Kb)
    Other Contributors
    Date Issued
    2015
    Subject
    Biology; Chemistry and chemical biology; Chemical and biological engineering; Biomedical engineering
    Degree
    Terms of Use
    In Copyright : this Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). https://rightsstatements.org/page/InC/1.0/;
    Full Citation
    Chemoenzymatic synthesis of heparin, D. M. Dickinson, J. Liu, R. J. Linhardt, Glycoscience: Biology and Medicine, N. Taniguchi, T. Endo, G. Hart, P. Seeberger, C.-H. Wong (Eds.), Springer, pp 419-426, 2015.
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    URI
    https://hdl.handle.net/20.500.13015/5363; https://doi.org/10.1007/978-4-431-54836-2_42-1
    Abstract
    Heparan sulfate is a polysaccharide that plays essential physiological functions in the animal kingdom. Heparin, a highly sulfated form of heparan sulfate, is a widely prescribed anticoagulant drug worldwide. The heparan sulfate and heparin isolated from natural sources are highly heterogeneous mixtures differing in polysaccharide chain lengths and sulfation patterns. The access to structurally defined heparan sulfate and heparin is critically important to probe the contribution of specific sulfated saccharide structures to biological functions as well as for the development of the next generation of heparin-based anticoagulant drugs. The synthesis of heparan sulfate and heparin, using a purely chemical approach, has proven extremely difficult, especially for targets larger than octasaccharides having a high degree of site-specific sulfation. A new chemoenzymatic method has emerged as an effective alternative approach. This method utilizes recombinant heparan sulfate biosynthetic enzymes combined with unnatural uridine diphosphate-monosaccharide donors. Recent examples demonstrate the successful synthesis of ultra-low molecular weight heparin, low-molecular weight heparin and bioengineered heparin with unprecedented efficiency. The new method opens the opportunity to develop improved heparin-based therapeutics.;
    Description
    Glycoscience: Biology and Medicine, N. Taniguchi, T. Endo, G. Hart, P. Seeberger, C. H. Wong (Eds.), Springer, pp 419-426; Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
    Department
    The Linhardt Research Labs.; The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS);
    Publisher
    Springer
    Relationships
    The Linhardt Research Labs Online Collection; Rensselaer Polytechnic Institute, Troy, NY; https://harc.rpi.edu/;
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    A full text version is available in DSpace@RPI;
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