Biology; Chemistry and chemical biology; Chemical and biological engineering; Biomedical engineering
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Glycoconjugate synthesis using chemoselective ligation, S. Cheng, P.L. Wantuch, M.E. Kizer, D.R. Middleton, R. Wang, M. DiBello, M. Li, X. Wang, X. Li, V. Ramachandiran, F.Y. Avci, F. Zhang, Xing Zhang, R.J. Linhardt, Organic & Biomolecular Chemistry, 17, 2646-2650, 2019.
Chemoselective ligation of carbohydrates and polypeptides was achieved using an adipic acid dihydrazide cross-linker. The reducing end of a carbohydrate is efficiently attached to peptides in two steps, constructing a glycoconjugate in high yield and with high regioselectivity, enabling the production of homogeneous glycoconjugates.;
Organic & Biomolecular Chemistry, 17, 2646-2650; Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
The Linhardt Research Labs.; The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS);
Royal Society of Chemistry
The Linhardt Research Labs Online Collection; Rensselaer Polytechnic Institute, Troy, NY; Organic and Biomolecular Chemistry; https://harc.rpi.edu/;