Biology; Chemistry and chemical biology; Chemical and biological engineering; Biomedical engineering
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Biodegradable and Bioactive Core-Shell Fibers for Tissue Engineering, L. Hou, X. Zhang, P.E. Mikael, L. Lin, W. Dong, Y. Zheng, T. J. Simmons, F. Zhang, R. J. Linhardt, ACS Omega, 2, 6321−6328, 2017.
Poly(glycerol sebacate) (PGS) has increasingly become a desirable biomaterial due to its elastic mechanical properties, biodegradability, and biocompatibility. Here, we report microfibrous core–shell mats of polycaprolactone (PCL)–PGS prepared using wet–wet coaxial electrospinning. The anticoagulant heparin was immobilized onto the surface of these electrospun fiber mats, and they were evaluated for their chemical, mechanical, and biological properties. The core–shell structure of PCL–PGS provided tunable degradation and mechanical properties. The slowly degrading PCL provided structural integrity, and the fast degrading PGS component increased fiber elasticity. Young’s modulus of PCL–PGS ranged from 5.6 to 15.7 MPa. The ultimate tensile stress ranged from 2.0 to 2.9 MPa, and these fibers showed elongation from 290 to 900%. The addition of PGS and grafting of heparin improved the attachment and proliferation of human umbilical vein endothelial cells. Core–shell PCL–PGS fibers demonstrate improved performance as three-dimensional fibrous mats for potential tissue-engineering applications.;
ACS Omega, 2, 6321−6328; Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
The Linhardt Research Labs.; The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS);
American Chemical Society (ACS)
The Linhardt Research Labs Online Collection; Rensselaer Polytechnic Institute, Troy, NY; ACS Omega; https://harc.rpi.edu/;
ACS AuthorChoice License; Open Access; A full text version is available in DSpace@RPI;