Biology; Chemistry and chemical biology; Chemical and biological engineering; Biomedical engineering
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Synthesis of 4-azido-N-acetylhexosamine uridine diphosphate donors: Clickable glycosaminoglycans, X. Zhang, D.E. Green, V.L. Schultz, L. Lin, X.Han, R. Wang, A. Yaksic, S.Y. Kim, P. L. DeAngelis, R. J. Linhardt, Journal of Organic Chemistry 82, 9910−9915, 2017.
Unnatural chemically modified nucleotide sugars UDP-4-N3-GlcNAc and UDP-4-N3-GalNAc were chemically synthesized for the first time. These unnatural UDP sugar products were then tested for incorporation into hyaluronan, heparosan, or chondroitin using polysaccharide synthases. UDP-4-N3-GlcNAc served as a chain termination substrate for hyaluronan or heparosan synthases; the resulting 4-N3-GlcNAc-terminated hyaluronan and heparosan were then successfully conjugated with Alexa Fluor 488 DIBO alkyne, demonstrating that this approach is generally applicable for labeling and detection of suitable glycosaminoglycans.;
Journal of Organic Chemistry 82, 9910−9915; Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
The Linhardt Research Labs.; The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS);
American Chemical Society (ACS)
The Linhardt Research Labs Online Collection; Rensselaer Polytechnic Institute, Troy, NY; Journal of Organic Chemistry; https://harc.rpi.edu/;