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dc.rights.licenseOpen Access
dc.contributor.authorLi, Shan
dc.contributor.authorLi, Junhui
dc.contributor.authorZhi, Zijian
dc.contributor.authorHu, Yaqin
dc.contributor.authorGe, Jian
dc.contributor.authorYe, Xingqian
dc.contributor.authorTian, Ding
dc.contributor.authorLinhardt, Robert J.
dc.contributor.authorChen, Shiguo
dc.date2017
dc.date.accessioned2022-06-23T04:28:45Z
dc.date.available2022-06-23T04:28:45Z
dc.date.issued2017-06-01
dc.identifier.citation4-O-Sulfation in sea cucumber fucodians contribute to reversing dyslipidiaemia caused by HFD, S. Li, J. Li, Z. Zhi, J. Ge, X. Ye, T. Ding, R. J. Linhardt, S. Chen, International Journal of Biological Macromolecules, 99, 96-104, 2017.
dc.identifier.issn18790003
dc.identifier.issn1418130
dc.identifier.urihttps://hdl.handle.net/20.500.13015/5388
dc.identifier.urihttps://doi.org/10.1016/j.ijbiomac.2017.01.145
dc.descriptionInternational Journal of Biological Macromolecules, 99, 96-104
dc.descriptionNote : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
dc.description.abstractFucodians extracted from sea cucumbers (SC-FUCs) possess linear chains with uniform repeating units. Sulfation patterns endow SC-FUCs unique structures and bioactivity. The present study investigated the anti-hyperlipidemic activity of two fucodians isolated from sea cucumbers Pearsonothuria graeffei (fuc-Pg) and Isostichopus badionotus (fuc-Ib). The results indicate fuc-Pg dominated with a 4-O-sulfation pattern shows strong activity in reducing body weight, regulating lipid disorder (TC, TG, HLD-C, and LDL-C level), improving liver function (liver weight, GOP, GPT, and TBA concentrations) and increasing adiponectin level (adiponectin concentration) caused by HFD. However, fuc-Ib dominated with a 2-O-sulfation pattern has only moderate effects. These results suggest that different sulfation pattern may contribute to the differences in the hyperlipidemic activities. Further analysis by quantitative reverse transcription-polymerase chain reaction and Western blot analysis indicate that Fuc-Pg can suppress the expression of CD 36, increase the level of PPARα and decrease the level of CYP7A1, thus, the transportation of fatty acids into liver tissue and lipid metabolism, while fuc-Ib had only limited effects. Our results indicated the sulfation pattern may contribute to anti-hyperlipidemic activity of fucodian, and fuc-Pg dominated with 4-O-sulfation shows better effect and could be further developed as a potential anti-hyperlipidemic food supplement.
dc.description.sponsorshipNational Natural Science Foundation of China
dc.languageen_US
dc.language.isoENG
dc.publisherElsevier
dc.relation.ispartofThe Linhardt Research Labs Online Collection
dc.relation.ispartofRensselaer Polytechnic Institute, Troy, NY
dc.relation.ispartofInternational Journal of Biological Macromolecules
dc.relation.urihttps://harc.rpi.edu/
dc.subjectBiology
dc.subjectChemistry and chemical biology
dc.subjectChemical and biological engineering
dc.subjectBiomedical engineering
dc.title4-O-Sulfation in sea cucumber fucodians contribute to reversing dyslipidiaemia caused by HFD
dc.typeArticle
dcterms.accessRightsA full text version is available in DSpace@RPI
dcterms.isPartOfJournal
dcterms.isVersionOfhttps://doi.org/10.1016/j.ijbiomac.2017.01.145
dc.rights.holderIn Copyright : this Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). https://rightsstatements.org/page/InC/1.0/
dc.creator.identifierhttps://orcid.org/0000-0003-2219-5833
dc.relation.departmentThe Linhardt Research Labs.
dc.relation.departmentThe Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)
rpi.description.pages96-104
rpi.description.volume99


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