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    Recent advances in biotechnology for heparin and heparan sulfate analysis

    Author
    Qiao, Meng; Lin, Lei; Xia, Ke; Lid, Jun; Zhang, Xing; Linhardt, Robert J.
    ORCID
    https://orcid.org/0000-0003-2219-5833
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    RECENT ADVANCES IN BIOTECHNOLOGY FOR HEPARIN AND HEPARAN.pdf (1.540Mb)
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    Date Issued
    2020-11-01
    Subject
    Biology; Chemistry and chemical biology; Chemical and biological engineering; Biomedical engineering
    Degree
    Terms of Use
    In Copyright : this Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). https://rightsstatements.org/page/InC/1.0/;
    Full Citation
    Recent advances in biotechnology for heparin and heparan sulfate analysis, Meng Qiao, Lei Lin, Ke Xia, Jun Lid, Xing Zhang, Robert J. Linhardt, Talanta 219, 121270, 2020.
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    URI
    https://hdl.handle.net/20.500.13015/5392; https://doi.org/10.1016/j.talanta.2020.121270
    Abstract
    Heparan sulfate (HS) is a class of linear, sulfated, anionic polysaccharides, called glycosaminoglycans (GAGs), which present on the mammalian cell surfaces and extracellular matrix. HS GAGs display a wide range of critical biological functions, particularly in cell signaling. HS is composed of repeating units of 1 → 4 glucosidically linked uronic acid and glucosamine residues. Heparin, a pharmacologically important version of HS, having higher sulfation and a higher content of iduronic acid than HS, is a widely used clinical anticoagulant. However, due to their heterogeneity and complex structure, HS and heparin are very challenging to analyze, limiting biological studies and even resulting in safety concerns in their therapeutic application. Therefore, reliable methods of structural analysis of HS and heparin are critically needed. In addition to the structural analysis of heparin, its concentration in blood needs to be closely monitored to avoid complications such as thrombocytopenia or hemorrhage caused by heparin overdose. This review summarizes the progress in biotechnological approaches in the structural characterization of HS and heparin over the past decade and includes the development of the ultrasensitive approaches for detection and measurement in biological samples.;
    Description
    Talanta 219, 121270; Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
    Department
    The Linhardt Research Labs.; The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS);
    Publisher
    Elsevier
    Relationships
    The Linhardt Research Labs Online Collection; Rensselaer Polytechnic Institute, Troy, NY; Talanta; https://harc.rpi.edu/;
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    A full text version is available in DSpace@RPI;
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