dc.contributor.author | Yu, Yanlei | |
dc.contributor.author | Bruzdoski, Karen | |
dc.contributor.author | Kostousov, Vadim | |
dc.contributor.author | Hensch, Lisa | |
dc.contributor.author | Hui, Shiu ki | |
dc.contributor.author | Siddiqui, Fakiha | |
dc.contributor.author | Farooqui, Amber | |
dc.contributor.author | Kouta, Ahmed | |
dc.contributor.author | Zhang, Fuming | |
dc.contributor.author | Fareed, Jawed | |
dc.contributor.author | Teruya, Jun | |
dc.contributor.author | Linhardt, Robert J. | |
dc.date | 2020 | |
dc.date.accessioned | 2022-06-23T04:45:58Z | |
dc.date.available | 2022-06-23T04:45:58Z | |
dc.date.issued | 2020-09-15 | |
dc.identifier.citation | Structural characterization of a clinically described heparin-like substance in plasma causing bleeding, Y. Yu, K. Bruzdoski, V. Kostousov, L. Hensch, S. Hui, F. Siddiqui, A. Farooqui, A. Kouta, F. Zhang, J. Fareed, J. Teruya, R. J. Linhardt, Carbohydrate Polymers, 244, 116443, 2020. | |
dc.identifier.issn | 1448617 | |
dc.identifier.uri | https://hdl.handle.net/20.500.13015/5394 | |
dc.identifier.uri | https://doi.org/10.1016/j.carbpol.2020.116443 | |
dc.description | Carbohydrate Polymers, 244, 116443 | |
dc.description | Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform. | |
dc.description.abstract | Heparin-like substances (HLS) have been described in various clinical situations, including in settings of liver disease associated with infection, transplant, and metastasis. HLS are generally attributed to circulating glycosaminoglycans. Initial results for this patient showed coagulopathy due to liver disease without HLS. Two weeks after liver transplantation, a 10 year-old female with liver failure patient began to bleed from catheter insertion sites, mouth, and nares and HLS was suspected. The patient subsequently died and these clinical samples resulted in the isolation of a single heparan sulfate (HS) present at high concentrations in the plasma. Analysis of this HS showed it had an intermediate between heparin and HS with low antithrombin-mediated anticoagulant activity. We speculate that this 10-year old patient might have a platelet function defect influenced by this unusual HS. Endothelial defects not measurable by our methods might have also contributed to the observed bleeding complications. | |
dc.description.sponsorship | National Institutes of Health | |
dc.language | en_US | |
dc.language.iso | ENG | |
dc.publisher | Elsevier | |
dc.relation.ispartof | The Linhardt Research Labs Online Collection | |
dc.relation.ispartof | Rensselaer Polytechnic Institute, Troy, NY | |
dc.relation.ispartof | Carbohydrate Polymers | |
dc.relation.uri | https://harc.rpi.edu/ | |
dc.subject | Biology | |
dc.subject | Chemistry and chemical biology | |
dc.subject | Chemical and biological engineering | |
dc.subject | Biomedical engineering | |
dc.title | Structural characterization of a clinically described heparin-like substance in plasma causing bleeding | |
dc.type | Article | |
dcterms.accessRights | A full text version is available in DSpace@RPI | |
dcterms.isPartOf | Journal | |
dcterms.isVersionOf | https://doi.org/10.1016/j.carbpol.2020.116443 | |
dc.rights.holder | In Copyright : this Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). https://rightsstatements.org/page/InC/1.0/ | |
dc.creator.identifier | https://orcid.org/0000-0003-2219-5833 | |
dc.relation.department | The Linhardt Research Labs. | |
dc.relation.department | The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS) | |
rpi.description.volume | 244 | |