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dc.contributor.authorYu, Yanlei
dc.contributor.authorBruzdoski, Karen
dc.contributor.authorKostousov, Vadim
dc.contributor.authorHensch, Lisa
dc.contributor.authorHui, Shiu ki
dc.contributor.authorSiddiqui, Fakiha
dc.contributor.authorFarooqui, Amber
dc.contributor.authorKouta, Ahmed
dc.contributor.authorZhang, Fuming
dc.contributor.authorFareed, Jawed
dc.contributor.authorTeruya, Jun
dc.contributor.authorLinhardt, Robert J.
dc.date2020
dc.date.accessioned2022-06-23T04:45:58Z
dc.date.available2022-06-23T04:45:58Z
dc.date.issued2020-09-15
dc.identifier.citationStructural characterization of a clinically described heparin-like substance in plasma causing bleeding, Y. Yu, K. Bruzdoski, V. Kostousov, L. Hensch, S. Hui, F. Siddiqui, A. Farooqui, A. Kouta, F. Zhang, J. Fareed, J. Teruya, R. J. Linhardt, Carbohydrate Polymers, 244, 116443, 2020.
dc.identifier.issn1448617
dc.identifier.urihttps://hdl.handle.net/20.500.13015/5394
dc.identifier.urihttps://doi.org/10.1016/j.carbpol.2020.116443
dc.descriptionCarbohydrate Polymers, 244, 116443
dc.descriptionNote : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
dc.description.abstractHeparin-like substances (HLS) have been described in various clinical situations, including in settings of liver disease associated with infection, transplant, and metastasis. HLS are generally attributed to circulating glycosaminoglycans. Initial results for this patient showed coagulopathy due to liver disease without HLS. Two weeks after liver transplantation, a 10 year-old female with liver failure patient began to bleed from catheter insertion sites, mouth, and nares and HLS was suspected. The patient subsequently died and these clinical samples resulted in the isolation of a single heparan sulfate (HS) present at high concentrations in the plasma. Analysis of this HS showed it had an intermediate between heparin and HS with low antithrombin-mediated anticoagulant activity. We speculate that this 10-year old patient might have a platelet function defect influenced by this unusual HS. Endothelial defects not measurable by our methods might have also contributed to the observed bleeding complications.
dc.description.sponsorshipNational Institutes of Health
dc.languageen_US
dc.language.isoENG
dc.publisherElsevier
dc.relation.ispartofThe Linhardt Research Labs Online Collection
dc.relation.ispartofRensselaer Polytechnic Institute, Troy, NY
dc.relation.ispartofCarbohydrate Polymers
dc.relation.urihttps://harc.rpi.edu/
dc.subjectBiology
dc.subjectChemistry and chemical biology
dc.subjectChemical and biological engineering
dc.subjectBiomedical engineering
dc.titleStructural characterization of a clinically described heparin-like substance in plasma causing bleeding
dc.typeArticle
dcterms.accessRightsA full text version is available in DSpace@RPI
dcterms.isPartOfJournal
dcterms.isVersionOfhttps://doi.org/10.1016/j.carbpol.2020.116443
dc.rights.holderIn Copyright : this Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). https://rightsstatements.org/page/InC/1.0/
dc.creator.identifierhttps://orcid.org/0000-0003-2219-5833
dc.relation.departmentThe Linhardt Research Labs.
dc.relation.departmentThe Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)
rpi.description.volume244


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