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    Synthesis of selected unnatural sugar nucleotides for biotechnological applications

    Author
    Qiao, Meng; Li, Bingzhi; Ji, Yuan; Lin, Lei; Linhardt, Robert; Zhang, Xing
    ORCID
    https://orcid.org/0000-0003-2219-5833
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    SYNTHESIS OF SELECTED UNNATURAL SUGAR NUCLEOTIDES FOR.pdf (2.536Mb)
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    Date Issued
    2021-01-01
    Subject
    Biology; Chemistry and chemical biology; Chemical and biological engineering; Biomedical engineering
    Degree
    Terms of Use
    In Copyright : this Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). https://rightsstatements.org/page/InC/1.0/;
    Full Citation
    Synthesis of selected unnatural sugar nucleotides for biotechnological applications, M. Qiao, B. Li, Y. Ji, L. Lin, R. J. Linhardt, X. Zhang, Critical Reviews in Biotechnology, 41, 47–62, 2021.
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    URI
    https://hdl.handle.net/20.500.13015/5411; https://doi.org/10.1080/07388551.2020.1844623
    Abstract
    Sugar nucleotides are the principal building blocks for the synthesis of most complex carbohydrates and are crucial intermediates in carbohydrate metabolism. Uridine diphosphate (UDP) monosaccharides are among the most common sugar nucleotide donors and are transferred to glycosyl acceptors by glycosyltransferases or synthases in glycan biosynthetic pathways. These natural nucleotide donors have great biological importance, however, the synthesis and application of unnatural sugar nucleotides that are not available from in vivo biosynthesis are not well explored. In this review, we summarize the progress in the preparation of unnatural sugar nucleotides, in particular, the widely studied UDP-GlcNAc/GalNAc analogs. We focus on the “two-block” synthetic pathway that is initiated from monosaccharides, in which the first block is the synthesis of sugar-1-phosphate and the second block is the diphosphate bond formation. The biotechnological applications of these unnatural sugar nucleotides showing their physiological and pharmacological potential are discussed.;
    Description
    Critical Reviews in Biotechnology, 41, 47–62; Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
    Department
    The Linhardt Research Labs.; The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS);
    Publisher
    Taylor and Francis
    Relationships
    The Linhardt Research Labs Online Collection; Rensselaer Polytechnic Institute, Troy, NY; Critical Reviews in Biotechnology; https://harc.rpi.edu/;
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    A full text version is available in DSpace@RPI;
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