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dc.contributor.authorQiao, Meng
dc.contributor.authorLi, Bingzhi
dc.contributor.authorJi, Yuan
dc.contributor.authorLin, Lei
dc.contributor.authorLinhardt, Robert
dc.contributor.authorZhang, Xing
dc.date2021
dc.date.accessioned2022-06-23T04:46:02Z
dc.date.available2022-06-23T04:46:02Z
dc.date.issued2021-01-01
dc.identifier.citationSynthesis of selected unnatural sugar nucleotides for biotechnological applications, M. Qiao, B. Li, Y. Ji, L. Lin, R. J. Linhardt, X. Zhang, Critical Reviews in Biotechnology, 41, 47–62, 2021.
dc.identifier.issn15497801
dc.identifier.issn7388551
dc.identifier.urihttps://hdl.handle.net/20.500.13015/5411
dc.identifier.urihttps://doi.org/10.1080/07388551.2020.1844623
dc.descriptionCritical Reviews in Biotechnology, 41, 47–62
dc.descriptionNote : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
dc.description.abstractSugar nucleotides are the principal building blocks for the synthesis of most complex carbohydrates and are crucial intermediates in carbohydrate metabolism. Uridine diphosphate (UDP) monosaccharides are among the most common sugar nucleotide donors and are transferred to glycosyl acceptors by glycosyltransferases or synthases in glycan biosynthetic pathways. These natural nucleotide donors have great biological importance, however, the synthesis and application of unnatural sugar nucleotides that are not available from in vivo biosynthesis are not well explored. In this review, we summarize the progress in the preparation of unnatural sugar nucleotides, in particular, the widely studied UDP-GlcNAc/GalNAc analogs. We focus on the “two-block” synthetic pathway that is initiated from monosaccharides, in which the first block is the synthesis of sugar-1-phosphate and the second block is the diphosphate bond formation. The biotechnological applications of these unnatural sugar nucleotides showing their physiological and pharmacological potential are discussed.
dc.description.sponsorshipNational Institutes of Health
dc.languageen_US
dc.language.isoENG
dc.publisherTaylor and Francis
dc.relation.ispartofThe Linhardt Research Labs Online Collection
dc.relation.ispartofRensselaer Polytechnic Institute, Troy, NY
dc.relation.ispartofCritical Reviews in Biotechnology
dc.relation.urihttps://harc.rpi.edu/
dc.subjectBiology
dc.subjectChemistry and chemical biology
dc.subjectChemical and biological engineering
dc.subjectBiomedical engineering
dc.titleSynthesis of selected unnatural sugar nucleotides for biotechnological applications
dc.typeArticle
dcterms.accessRightsA full text version is available in DSpace@RPI
dcterms.isPartOfJournal
dcterms.isVersionOfhttps://doi.org/10.1080/07388551.2020.1844623
dc.rights.holderIn Copyright : this Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). https://rightsstatements.org/page/InC/1.0/
dc.creator.identifierhttps://orcid.org/0000-0003-2219-5833
dc.relation.departmentThe Linhardt Research Labs.
dc.relation.departmentThe Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)
rpi.description.pages47-62
rpi.description.volume41


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