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dc.contributor.authorShionoya, Kento
dc.contributor.authorSuzuki, Takehiro
dc.contributor.authorTakada, Mako
dc.contributor.authorSato, Kazuki
dc.contributor.authorOnishi, Shoichi
dc.contributor.authorDohmae, Naoshi
dc.contributor.authorNishino, Koichiro
dc.contributor.authorWada, Takeshi
dc.contributor.authorLinhardt, Robert J.
dc.contributor.authorToida, Toshihiko
dc.contributor.authorHigashi, Kyohei
dc.date2022
dc.date.accessioned2022-06-27T15:33:48Z
dc.date.available2022-06-27T15:33:48Z
dc.date.issued2022-05-31
dc.identifier.citationComprehensive analysis of chondroitin sulfate and aggrecan in the head cartilage of bony fishes: Identification of proteoglycans in the head cartilage of sturgeon, K. Shionoya, T. Suzuki, M. Takada, K. Sato, S. Onishi, N. Dohmae, K. Nishino, T. Wada, R. J. Linhardt, T. Toida, K. Higashi, International Journal of Biological Macromolecules, 208, 333–342, 2022.
dc.identifier.issn18790003
dc.identifier.issn1418130
dc.identifier.urihttps://doi.org/10.1016/j.ijbiomac.2022.03.125
dc.identifier.urihttps://hdl.handle.net/20.500.13015/5427
dc.descriptionInternational Journal of Biological Macromolecules, 208, 333–342
dc.descriptionNote : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
dc.description.abstractCartilage in the head of sturgeon or salmon has been gaining attention as a rich source of functional chondroitin sulfate (CS) or proteoglycans. Although the cartilage was found in the heads of other bony fishes, the structure of CS and its core protein, especially aggrecan, was not fully investigated. In this study, comprehensive analysis of CS and aggrecan in the head cartilage of 10 bony fishes including sturgeon and salmon was performed. The 4-O-sulfation to 6-O-sulfation ratio (4S/6S ratio; S: sulfate residue) of CS in Perciformes was ≧1.0, while the 4S/6S ratios of CS from sturgeons and salmon were less than 0.5. Dot blotting and proteomic analysis revealed that aggrecan was a major core protein in head cartilage of all bony fishes. These results suggest that the head cartilage of bony fishes is a promising source for the preparation of CS or proteoglycans as a health food ingredient.
dc.description.urihttps://login.libproxy.rpi.edu/login?url=https://doi.org/10.1016/j.ijbiomac.2022.03.125
dc.languageen_US
dc.language.isoENG
dc.relation.ispartofThe Linhardt Research Labs Online Collection
dc.relation.ispartofRensselaer Polytechnic Institute, Troy, NY
dc.relation.ispartofInternational Journal of Biological Macromolecules
dc.relation.urihttps://harc.rpi.edu/
dc.subjectBiology
dc.subjectChemistry and chemical biology
dc.subjectChemical and biological engineering
dc.subjectBiomedical engineering
dc.titleComprehensive analysis of chondroitin sulfate and aggrecan in the head cartilage of bony fishes: Identification of proteoglycans in the head cartilage of sturgeon
dc.typeArticle
dcterms.accessRightshttps://login.libproxy.rpi.edu/login?url=https://doi.org/10.1016/j.ijbiomac.2022.03.125
dcterms.isPartOfJournal
dcterms.isVersionOfhttps://doi.org/10.1016/j.ijbiomac.2022.03.125
dc.rights.holderIn Copyright : this Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). https://rightsstatements.org/page/InC/1.0/
dc.creator.identifierhttps://orcid.org/0000-0003-2219-5833
dc.relation.departmentThe Linhardt Research Labs.
dc.relation.departmentThe Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)
rpi.description.pages333-342
rpi.description.volume208


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