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dc.contributor.authorYu, Yanlei
dc.contributor.authorFu, Li
dc.contributor.authorHe, Peng
dc.contributor.authorXia, Ke
dc.contributor.authorVarghese, Sony
dc.contributor.authorWang, Hong
dc.contributor.authorZhang, Fuming
dc.contributor.authorDordick, Jonathan
dc.contributor.authorLinhardt, Robert J.
dc.date2022
dc.date.accessioned2022-06-27T15:33:48Z
dc.date.available2022-06-27T15:33:48Z
dc.date.issued2022-03-18
dc.identifier.citationChemobiocatalytic Synthesis of a Low Molecular Weight Heparin, Y. Yu, L. Fu, P. He, K. Xia, S. Varghese, H. Wang, F. Zhang, J. Dordick, R.J. Linhardt, ACS Chemical Biology,17, 637-646, 2022.
dc.identifier.issn15548937
dc.identifier.issn15548929
dc.identifier.urihttps://doi.org/10.1021/acschembio.1c00928
dc.identifier.urihttps://hdl.handle.net/20.500.13015/5428
dc.descriptionACS Chemical Biology,17, 637-646
dc.descriptionNote : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
dc.description.abstractHeparin products are widely used clinical anticoagulants essential in the practice of modern medicine. Low-molecular-weight heparins (LMWHs) are currently prepared by the controlled chemical or enzymatic depolymerization of unfractionated heparins (UFHs) that are extracted from animal tissues. In many clinical applications, LMWHs have displaced UFHs and currently comprise over 60% of the heparin market. In the past, our laboratory has made extensive efforts to prepare bioengineered UFHs relying on a chemoenzymatic process to address concerns about animal-sourced UFHs. The current study describes the use of a novel chemoenzymatic process to prepare a chemobiosynthetic LMWH from a low-molecular-weight heparosan. The resulting chemobiocatalytic LMWH matches most of the United States pharmacopeial specifications for enoxaparin, a LMWH prepared through the base-catalyzed depolymerization of animal-derived UFH.
dc.description.sponsorshipNational Science Foundation
dc.description.urihttps://login.libproxy.rpi.edu/login?url=https://doi.org/10.1021/acschembio.1c00928
dc.languageen_US
dc.language.isoENG
dc.relation.ispartofThe Linhardt Research Labs Online Collection
dc.relation.ispartofRensselaer Polytechnic Institute, Troy, NY
dc.relation.ispartofACS Chemical Biology
dc.relation.urihttps://harc.rpi.edu/
dc.subjectBiology
dc.subjectChemistry and chemical biology
dc.subjectChemical and biological engineering
dc.subjectBiomedical engineering
dc.titleChemobiocatalytic Synthesis of a Low Molecular Weight Heparin
dc.typeArticle
dcterms.accessRightshttps://login.libproxy.rpi.edu/login?url=https://doi.org/10.1021/acschembio.1c00928
dcterms.isPartOfJournal
dcterms.isVersionOfhttps://doi.org/10.1021/acschembio.1c00928
dc.rights.holderIn Copyright : this Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). https://rightsstatements.org/page/InC/1.0/
dc.creator.identifierhttps://orcid.org/0000-0003-2219-5833
dc.relation.departmentThe Linhardt Research Labs.
dc.relation.departmentThe Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)
rpi.description.pages637-646
rpi.description.volume17


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