dc.contributor.author | Yu, Yanlei | |
dc.contributor.author | Fu, Li | |
dc.contributor.author | He, Peng | |
dc.contributor.author | Xia, Ke | |
dc.contributor.author | Varghese, Sony | |
dc.contributor.author | Wang, Hong | |
dc.contributor.author | Zhang, Fuming | |
dc.contributor.author | Dordick, Jonathan | |
dc.contributor.author | Linhardt, Robert J. | |
dc.date | 2022 | |
dc.date.accessioned | 2022-06-27T15:33:48Z | |
dc.date.available | 2022-06-27T15:33:48Z | |
dc.date.issued | 2022-03-18 | |
dc.identifier.citation | Chemobiocatalytic Synthesis of a Low Molecular Weight Heparin, Y. Yu, L. Fu, P. He, K. Xia, S. Varghese, H. Wang, F. Zhang, J. Dordick, R.J. Linhardt, ACS Chemical Biology,17, 637-646, 2022. | |
dc.identifier.issn | 15548937 | |
dc.identifier.issn | 15548929 | |
dc.identifier.uri | https://doi.org/10.1021/acschembio.1c00928 | |
dc.identifier.uri | https://hdl.handle.net/20.500.13015/5428 | |
dc.description | ACS Chemical Biology,17, 637-646 | |
dc.description | Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform. | |
dc.description.abstract | Heparin products are widely used clinical anticoagulants essential in the practice of modern medicine. Low-molecular-weight heparins (LMWHs) are currently prepared by the controlled chemical or enzymatic depolymerization of unfractionated heparins (UFHs) that are extracted from animal tissues. In many clinical applications, LMWHs have displaced UFHs and currently comprise over 60% of the heparin market. In the past, our laboratory has made extensive efforts to prepare bioengineered UFHs relying on a chemoenzymatic process to address concerns about animal-sourced UFHs. The current study describes the use of a novel chemoenzymatic process to prepare a chemobiosynthetic LMWH from a low-molecular-weight heparosan. The resulting chemobiocatalytic LMWH matches most of the United States pharmacopeial specifications for enoxaparin, a LMWH prepared through the base-catalyzed depolymerization of animal-derived UFH. | |
dc.description.sponsorship | National Science Foundation | |
dc.description.uri | https://login.libproxy.rpi.edu/login?url=https://doi.org/10.1021/acschembio.1c00928 | |
dc.language | en_US | |
dc.language.iso | ENG | |
dc.relation.ispartof | The Linhardt Research Labs Online Collection | |
dc.relation.ispartof | Rensselaer Polytechnic Institute, Troy, NY | |
dc.relation.ispartof | ACS Chemical Biology | |
dc.relation.uri | https://harc.rpi.edu/ | |
dc.subject | Biology | |
dc.subject | Chemistry and chemical biology | |
dc.subject | Chemical and biological engineering | |
dc.subject | Biomedical engineering | |
dc.title | Chemobiocatalytic Synthesis of a Low Molecular Weight Heparin | |
dc.type | Article | |
dcterms.accessRights | https://login.libproxy.rpi.edu/login?url=https://doi.org/10.1021/acschembio.1c00928 | |
dcterms.isPartOf | Journal | |
dcterms.isVersionOf | https://doi.org/10.1021/acschembio.1c00928 | |
dc.rights.holder | In Copyright : this Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). https://rightsstatements.org/page/InC/1.0/ | |
dc.creator.identifier | https://orcid.org/0000-0003-2219-5833 | |
dc.relation.department | The Linhardt Research Labs. | |
dc.relation.department | The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS) | |
rpi.description.pages | 637-646 | |
rpi.description.volume | 17 | |