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dc.contributor.authorNing, Z.
dc.contributor.authorLang, K.
dc.contributor.authorXia, K.
dc.contributor.authorLinhardt, Robert J.
dc.contributor.authorGross, R.
dc.date2022
dc.date.accessioned2022-06-27T15:33:49Z
dc.date.available2022-06-27T15:33:49Z
dc.date.issued2022
dc.identifier.citationLipase Catalyzed Synthesis and Characterization of Poly (Glycerol-Sebacate), Z. Ning, K. Lang, K. Xia, R. J. Linhardt, R. Gross, Biomacromolecules, 23, 398-408, 2022.
dc.identifier.urihttps://doi.org/10.1021/acs.biomac.1c01351
dc.identifier.urihttps://hdl.handle.net/20.500.13015/5434
dc.descriptionBiomacromolecules, 23, 398-408
dc.descriptionNote : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
dc.description.abstractThis study demonstrated that immobilized Candida antarctica lipase B (N435) catalysis in bulk leads to higher molecular weight poly(glycerol sebacate), PGS, than self-catalyzed condensation polymerization. Since the glass-transition temperature, fragility, modulus, and strength for rubbery networks are inversely dependent on the concentration of chain ends, higher molecular weight PGS prepolymers will enable the preparation of cross-linked PGS matrices with unique mechanical properties. The evolution of molecular species during the prepolymerization step conducted at 120 °C for 24 h, prior to enzyme addition, revealed regular decreases in sebacic acid and glycerol-sebacate dimer with corresponding increases in oligomers with chain lengths from 3 to 7 units such that a homogeneous liquid substrate has resulted. At 67 h, for N435-catalyzed PGS synthesis, the carboxylic acid conversion reached 82% without formation of a gel fraction, and number-average molecular weight (Mn) and weight-average molecular weight (Mw) values reached 6000 and 59 400 g/mol, respectively. In contrast, self-catalyzed PGS condensation polymerizations required termination at 55 h to avoid gelation, reached 72% conversion, and Mn and Mw values of 2600 and 13 800 g/mol, respectively. We also report the extent that solvent fractionation can enrich PGS in higher molecular weight chains. The use of methanol as a nonsolvent increased Mn and Mw by 131.7 and 18.3%, respectively, and narrower dispersity (Đ) decreased by 47.7% relative to the nonfractionated product.
dc.description.urihttps://login.libproxy.rpi.edu/login?url=https://doi.org/10.1021/acs.biomac.1c01351
dc.languageen_US
dc.language.isoENG
dc.relation.ispartofThe Linhardt Research Labs Online Collection
dc.relation.ispartofRensselaer Polytechnic Institute, Troy, NY
dc.relation.urihttps://harc.rpi.edu/
dc.subjectBiology
dc.subjectChemistry and chemical biology
dc.subjectChemical and biological engineering
dc.subjectBiomedical engineering
dc.titleLipase Catalyzed Synthesis and Characterization of Poly (Glycerol-Sebacate)
dc.typeArticle
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dcterms.isVersionOfhttps://doi.org/10.1021/acs.biomac.1c01351
dc.rights.holderIn Copyright : this Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). https://rightsstatements.org/page/InC/1.0/
dc.creator.identifierhttps://orcid.org/0000-0003-2219-5833
dc.relation.departmentThe Linhardt Research Labs.
dc.relation.departmentThe Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)


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