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dc.contributor.authorLu, Jiahui
dc.contributor.authorLi, Yanying
dc.contributor.authorZhang, Anqiang
dc.contributor.authorLiu, Weiming
dc.contributor.authorWang, Xingli
dc.contributor.authorZhang, Fuming
dc.contributor.authorLinhardt, Robert J.
dc.contributor.authorLin, Zhibin
dc.contributor.authorSun, Peilong
dc.date2021
dc.date.accessioned2022-06-27T15:36:07Z
dc.date.available2022-06-27T15:36:07Z
dc.date.issued2021-08-01
dc.identifier.citationSustained release of Ganoderma lucidum antitumor drugs using a sandwich structured material prepared by electrospinning, A. Zhang J. Lu, Y. Li, W. Liu, X. Wang, F. Zhang, R. J. Linhardt, Z. Lin, P. Sun, Journal of Drug Delivery Science and Technology, 64, 102627, 2021.
dc.identifier.issn17732247
dc.identifier.urihttps://doi.org/10.1016/j.jddst.2021.102627
dc.identifier.urihttps://hdl.handle.net/20.500.13015/5445
dc.descriptionJournal of Drug Delivery Science and Technology, 64, 102627
dc.descriptionNote : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
dc.description.abstractIn cancer therapy, there still remains great challenges such as controlling cancer metastasis and the side effects from chemotherapy. Many anti-cancer drugs have cytotoxicity to normal cell with a high concentration, on the other hand, the anti-cancer effect will not be ideal if it didn’t reach the effective concentrations. So there is a way to make balance between the cytotoxicity and effective concentrations, sustained release can not only prolong the duration of the effective concentration but also reduce the time of peak concentration. Herein, we designed a sandwich structured antitumor composite with a three-layer film including: i) the top and bottom layers of ethyl cellulose (EC) containing Ganoderma lucidum triterpenes (GLT); ii) the middle layer of polyvinyl alcohol (PVA) containing G. lucidum polysaccharides (GLP). The films were fabricated layer-by-layer using electrospinning with the aim of providing the sustained release of the antitumor activity of GLT and GLP for use in cancer therapy. This sandwich structured material has potential for sustained antitumor release, high loading capacity (1.6% for GLT and 7.9% for GLP) and large surface area. The morphology, structure, biocompatibility, and the release profile of the encapsulated GLP and GLT in this fabricated composite were characterized. The in vitro antitumor effects of this drug film were studied using carcinoma cells, as SGC-7901, A549, Hela and Caco-2, with the IC50 of 51.2, 90.7, 93.0 and 21.7 μg/mL, respectively. In brief, this medical film achieved a good antitumor effect at the cellular level.
dc.description.sponsorshipNatural Science Foundation of Zhejiang Province
dc.description.urihttps://login.libproxy.rpi.edu/login?url=https://doi.org/10.1016/j.jddst.2021.102627
dc.languageen_US
dc.language.isoENG
dc.relation.ispartofThe Linhardt Research Labs Online Collection
dc.relation.ispartofRensselaer Polytechnic Institute, Troy, NY
dc.relation.ispartofJournal of Drug Delivery Science and Technology
dc.relation.urihttps://harc.rpi.edu/
dc.subjectBiology
dc.subjectChemistry and chemical biology
dc.subjectChemical and biological engineering
dc.subjectBiomedical engineering
dc.titleSustained release of Ganoderma lucidum antitumor drugs using a sandwich structured material prepared by electrospinning
dc.typeArticle
dcterms.accessRightshttps://login.libproxy.rpi.edu/login?url=https://doi.org/10.1016/j.jddst.2021.102627
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dcterms.isVersionOfhttps://doi.org/10.1016/j.jddst.2021.102627
dc.rights.holderIn Copyright : this Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). https://rightsstatements.org/page/InC/1.0/
dc.creator.identifierhttps://orcid.org/0000-0003-2219-5833
dc.relation.departmentThe Linhardt Research Labs.
dc.relation.departmentThe Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)
rpi.description.volume64


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