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dc.contributor.authorZheng, Jie
dc.contributor.authorLi, Bingzhi
dc.contributor.authorJi, Yuan
dc.contributor.authorChen, Yin
dc.contributor.authorLv, Xun
dc.contributor.authorZhang, Xing
dc.contributor.authorLinhardt, Robert J.
dc.identifier.citationProlonged release and shelf-life of anticoagulant sulfated polysaccharides encapsulated with ZIF-8, J. Zheng, B. Li, Y. Ji, Yin C. Xun Lv, X. Zhang, R. J. Linhardt, International Journal of Biological Macromolecules, 183, 1174-1183, 2021.
dc.descriptionInternational Journal of Biological Macromolecules, 183, 1174-1183
dc.descriptionNote : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
dc.description.abstractNatural active polysaccharides are attracting increased attention from pharmaceutical industries for their valuable biological activities. However, the application of polysaccharides has been restricted due to their relatively large molecular weight, complex structure, and instability. Metal-organic frameworks (MOFs) have emerged to help deliver cargo to specific locations, achieving the objectives of eliminating the potential damage to the body, protecting the drugs, and improving therapeutic effectiveness. Here, a pH-responsive zeolitic imidazolate framework (ZIF-8) was synthesized to encapsulated three sulfated polysaccharides (heparin, fucan sulfate, fucosylated chondroitin sulfate) and a non-sulfated polysaccharide, hyaluronic acid. The resulting polysaccharides@ZIF-8 biocomposites showed differences in terms of morphology, particle size, encapsulation, and release efficiency. These biocomposites retained antithrombotic activity and the framework ZIF-8 effectively protected these polysaccharides from degradation and prolonged shelf-life of the anticoagulants from the unfavorable environment.
dc.description.sponsorshipNational Natural Science Foundation of China
dc.relation.ispartofThe Linhardt Research Labs Online Collection
dc.relation.ispartofRensselaer Polytechnic Institute, Troy, NY
dc.relation.ispartofInternational Journal of Biological Macromolecules
dc.subjectChemistry and chemical biology
dc.subjectChemical and biological engineering
dc.subjectBiomedical engineering
dc.titleProlonged release and shelf-life of anticoagulant sulfated polysaccharides encapsulated with ZIF-8
dc.rights.holderIn Copyright : this Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s).
dc.relation.departmentThe Linhardt Research Labs.
dc.relation.departmentThe Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)

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