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dc.contributor.authorGarrudo, F.F.F.
dc.contributor.authorMikael, P.E.
dc.contributor.authorRodrigues, C.A.V.
dc.contributor.authorUdangawa, R.W.
dc.contributor.authorParadiso, P.
dc.contributor.authorChapman, C.A.
dc.contributor.authorHoffman, P.
dc.contributor.authorColaço, R.
dc.contributor.authorCabral, J.M.S.
dc.contributor.authorMorgado, J.
dc.contributor.authorLinhardt, Robert J.
dc.contributor.authorFerreir, F.C.
dc.date2021
dc.date.accessioned2022-06-27T15:36:58Z
dc.date.available2022-06-27T15:36:58Z
dc.date.issued2021-01-01
dc.identifier.citationPolyaniline-Polycaprolactone Fibers for Neural Applications: Electroconductivity Enhanced by Pseudo-Doping, F. F. F. Garrudo, P. E. Mikael, C. A. V. Rodrigues, R. W. Udangawa, P. Paradiso, C. A. Chapman, P. Hoffman, R. Colaço, J. M. S. Cabral, J. Morgado, R. J. Linhardt, F. C. Ferreir, Materials Science & Engineering C, 120, 111680, 2021.
dc.identifier.issn18730191
dc.identifier.issn9284931
dc.identifier.urihttps://doi.org/10.1016/j.msec.2020.111680
dc.identifier.urihttps://hdl.handle.net/20.500.13015/5463
dc.descriptionMaterials Science & Engineering C, 120, 111680
dc.descriptionNote : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
dc.description.abstractReplenishing neurons in patients with neurodegenerative diseases is one of the ultimate therapies for these progressive, debilitating and fatal diseases. Electrical stimulation can improve neuron stem cell differentiation but requires a reliable nanopatterned electroconductive substrate. Potential candidate substrates are polycaprolactone (PCL) – polyaniline:camphorsulfonic acid (PANI:CSA) nanofibers, but their nanobiophysical properties need to be finetuned. The present study investigates the use of the pseudo-doping effect on the optimization of the electroconductivity of these polyaniline-based electrospun nanofibers. This was performed by developing a new solvent system that comprises a mixture of hexafluoropropanol (HFP) and trifluoroethanol (TFE). For the first time, an electroconductivity so high as 0.2 S cm−1 was obtained for, obtained from a TFE:HFP 50/50 vol% solution, while maintaining fiber biocompatibility. The physicochemical mechanisms behind these changes were studied. The results suggest HFP promotes changes on PANI chains conformations through pseudo-doping, leading to the observed enhancement in electroconductivity. The consequences of such change in the nanofabrication of PCL-PANI fibers include an increase in fiber diameter (373 ± 172 nm), a decrease in contact angle (42 ± 3°) and a decrease in Young modulus (1.6 ± 0.5 MPa), making these fibers interesting candidates for neural tissue engineering. Electrical stimulation of differentiating neural stem cells was performed using AC electrical current. Positive effects on cell alignment and gene expression (DCX, MAP2) are observed. The novel optimized platform shows promising applications for (1) building in vitro platforms for drug screening, (2) interfaces for deep-brain electrodes; and (3) fully grown and functional neurons transplantation.
dc.description.sponsorshipNational Institutes of Health
dc.languageen_US
dc.language.isoENG
dc.relation.ispartofThe Linhardt Research Labs Online Collection
dc.relation.ispartofRensselaer Polytechnic Institute, Troy, NY
dc.relation.ispartofMaterials Science and Engineering C
dc.relation.urihttps://harc.rpi.edu/
dc.subjectBiology
dc.subjectChemistry and chemical biology
dc.subjectChemical and biological engineering
dc.subjectBiomedical engineering
dc.titlePolyaniline-Polycaprolactone Fibers for Neural Applications: Electroconductivity Enhanced by Pseudo-Doping
dc.typeArticle
dcterms.isPartOfJournal
dcterms.isVersionOfhttps://doi.org/10.1016/j.msec.2020.111680
dc.rights.holderIn Copyright : this Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). https://rightsstatements.org/page/InC/1.0/
dc.creator.identifierhttps://orcid.org/0000-0003-2219-5833
dc.relation.departmentThe Linhardt Research Labs.
dc.relation.departmentThe Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)
rpi.description.volume120


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