Recent Progress and Advanced Technology in Carbohydrate-Based Drug Development

Authors
Pan, Lin
Cai, Chao
Liu, Chanjuan
Liu, Di
Li, Guoyun
Linhardt, Robert J.
Yu, Guangli
ORCID
https://orcid.org/0000-0003-2219-5833
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Other Contributors
Issue Date
2021-06-01
Keywords
Biology , Chemistry and chemical biology , Chemical and biological engineering , Biomedical engineering
Degree
Terms of Use
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Full Citation
Recent Progress and Advanced Technology in Carbohydrate-Based Drug Development, L. Pan, C. Cai, C. Liu, D. Liu, G. Li, R. J. Linhardt, G. Yu, Current Opinions in Biotechnology, 69, 191–198, 2021.
Abstract
Carbohydrates, one of the most abundant and widespread biomolecules in nature, play indispensable roles in diverse biological functions, and represent a treasure trove of untapped potential for pharmaceutical applications. Here, we provide a brief overview of carbohydrate-based drug development (CBDD) over the past two decades. More importantly, advanced techniques and methodologies related to CBDD are emerging, including enzymatic synthesis, metabolic engineering, site-specific glycoconjugation, carbohydrate libraries and microarrays as well as carbohydrate-gut microbiome evaluation. These technologies have dramatically accelerated the speed of CBDD. The recently approved drugs and emerging techniques summarized herein will inspire new sights into potential opportunities to discover novel carbohydrate drugs.
Description
Current Opinions in Biotechnology, 69, 191–198
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Department
The Linhardt Research Labs.
The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)
Publisher
Relationships
The Linhardt Research Labs Online Collection
Rensselaer Polytechnic Institute, Troy, NY
Current Opinion in Biotechnology
https://harc.rpi.edu/
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https://login.libproxy.rpi.edu/login?url=https://doi.org/10.1016/j.copbio.2020.12.023