Biology; Chemistry and chemical biology; Chemical and biological engineering; Biomedical engineering
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Recent Progress and Advanced Technology in Carbohydrate-Based Drug Development, L. Pan, C. Cai, C. Liu, D. Liu, G. Li, R. J. Linhardt, G. Yu, Current Opinions in Biotechnology, 69, 191–198, 2021.
Carbohydrates, one of the most abundant and widespread biomolecules in nature, play indispensable roles in diverse biological functions, and represent a treasure trove of untapped potential for pharmaceutical applications. Here, we provide a brief overview of carbohydrate-based drug development (CBDD) over the past two decades. More importantly, advanced techniques and methodologies related to CBDD are emerging, including enzymatic synthesis, metabolic engineering, site-specific glycoconjugation, carbohydrate libraries and microarrays as well as carbohydrate-gut microbiome evaluation. These technologies have dramatically accelerated the speed of CBDD. The recently approved drugs and emerging techniques summarized herein will inspire new sights into potential opportunities to discover novel carbohydrate drugs.;
Current Opinions in Biotechnology, 69, 191–198; Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
The Linhardt Research Labs.; The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS);
The Linhardt Research Labs Online Collection; Rensselaer Polytechnic Institute, Troy, NY; Current Opinion in Biotechnology; https://harc.rpi.edu/;