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    Xylosyltransferase 2 deficiency and organ homeostasis

    Author
    Ferencz, Beatrix; Condac, Eduard; Poudel, Nabin; Munteanu, Maria Cristina; Sivasami, Pulavendran; Choudhury, Biswa; Naidu, Nandita Natasha; Zhang, Fuming; Breshears, Melanie; Linhardt, Robert J.; Hinsdale, Myron E.
    ORCID
    https://orcid.org/0000-0003-2219-5833
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    Date Issued
    2020-12-01
    Subject
    Biology; Chemistry and chemical biology; Chemical and biological engineering; Biomedical engineering
    Degree
    Terms of Use
    In Copyright : this Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). https://rightsstatements.org/page/InC/1.0/;
    Full Citation
    Xylosyltransferase 2 deficiency and organ homeostasis, B. Ferencz, E. Condac, N. Poudel, M.C. Munteanu, P. Sivasami, B. Choudhury, N.N. Naidu, F. Zhang, M. Breshears, R.J. Linhardt, M.E. Hinsdale, Glycoconjugate Journal, 37, 755-765, 2020.
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    URI
    https://doi.org/10.1007/s10719-020-09945-9; https://hdl.handle.net/20.500.13015/5475
    Abstract
    In this paper we characterize the function of Xylosyltransferase 2 (XylT2) in different tissues to investigate the role XylT2 has in the proteoglycan (PG) biochemistry of multiple organs. The results show that in all organs examined there is a widespread and significant decrease in total XylT activity in Xylt2 knock out mice (Xylt2-/-). This decrease results in increased organ weight differences in lung, heart, and spleen. These findings, in addition to our previous findings of increased liver and kidney weight with loss of serum XylT activity, suggest systemic changes in organ function due to loss of XylT2 activity. The Xylt2-/- mice have splenomegaly due to enlargement of the red pulp area and enhanced pulmonary response to bacterial liposaccharide. Tissue glycosaminoglycan composition changes are also found. These results demonstrate a role of XylT2 activity in multiple organs and their PG content. Because the residual XylT activity in the Xylt2-/- is due to xylosyltransferase 1 (XylT1), these studies indicate that both XylT1 and XylT2 have important roles in PG biosynthesis and organ homeostasis.;
    Description
    Glycoconjugate Journal, 37, 755-765; Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
    Department
    The Linhardt Research Labs.; The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS);
    Relationships
    The Linhardt Research Labs Online Collection; Rensselaer Polytechnic Institute, Troy, NY; Glycoconjugate Journal; https://harc.rpi.edu/;
    Access
    https://login.libproxy.rpi.edu/login?url=https://doi.org/10.1007/s10719-020-09945-9;
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