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dc.contributor.authorFerencz, Beatrix
dc.contributor.authorCondac, Eduard
dc.contributor.authorPoudel, Nabin
dc.contributor.authorMunteanu, Maria Cristina
dc.contributor.authorSivasami, Pulavendran
dc.contributor.authorChoudhury, Biswa
dc.contributor.authorNaidu, Nandita Natasha
dc.contributor.authorZhang, Fuming
dc.contributor.authorBreshears, Melanie
dc.contributor.authorLinhardt, Robert J.
dc.contributor.authorHinsdale, Myron E.
dc.identifier.citationXylosyltransferase 2 deficiency and organ homeostasis, B. Ferencz, E. Condac, N. Poudel, M.C. Munteanu, P. Sivasami, B. Choudhury, N.N. Naidu, F. Zhang, M. Breshears, R.J. Linhardt, M.E. Hinsdale, Glycoconjugate Journal, 37, 755-765, 2020.
dc.descriptionGlycoconjugate Journal, 37, 755-765
dc.descriptionNote : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
dc.description.abstractIn this paper we characterize the function of Xylosyltransferase 2 (XylT2) in different tissues to investigate the role XylT2 has in the proteoglycan (PG) biochemistry of multiple organs. The results show that in all organs examined there is a widespread and significant decrease in total XylT activity in Xylt2 knock out mice (Xylt2-/-). This decrease results in increased organ weight differences in lung, heart, and spleen. These findings, in addition to our previous findings of increased liver and kidney weight with loss of serum XylT activity, suggest systemic changes in organ function due to loss of XylT2 activity. The Xylt2-/- mice have splenomegaly due to enlargement of the red pulp area and enhanced pulmonary response to bacterial liposaccharide. Tissue glycosaminoglycan composition changes are also found. These results demonstrate a role of XylT2 activity in multiple organs and their PG content. Because the residual XylT activity in the Xylt2-/- is due to xylosyltransferase 1 (XylT1), these studies indicate that both XylT1 and XylT2 have important roles in PG biosynthesis and organ homeostasis.
dc.description.sponsorshipNational Institutes of Health
dc.relation.ispartofThe Linhardt Research Labs Online Collection
dc.relation.ispartofRensselaer Polytechnic Institute, Troy, NY
dc.relation.ispartofGlycoconjugate Journal
dc.subjectChemistry and chemical biology
dc.subjectChemical and biological engineering
dc.subjectBiomedical engineering
dc.titleXylosyltransferase 2 deficiency and organ homeostasis
dc.rights.holderIn Copyright : this Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s).
dc.relation.departmentThe Linhardt Research Labs.
dc.relation.departmentThe Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)

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