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dc.contributor.authorLang, K.
dc.contributor.authorBhattacharya, S.
dc.contributor.authorNing, Z.
dc.contributor.authorSánchez-Leija, R.J.
dc.contributor.authorBramson, M.T.K.
dc.contributor.authorCentore, R.
dc.contributor.authorCorr, D.T.
dc.contributor.authorLinhardt, Robert J.
dc.contributor.authorGross, R.A.
dc.date2020
dc.date.accessioned2022-06-27T15:40:48Z
dc.date.available2022-06-27T15:40:48Z
dc.date.issued2020
dc.identifier.citationEnzymatic polymerization of poly(glycerol-1,8-octanediol-sebacate): versatile PGS analogs that form mono-component biodegradable fiber scaffolds, K. Lang, S. Bhattacharya, Z. Ning, R. J. Sánchez-Leija, M.T. K. Bramson, R. Centore, D. T. Corr, R. J. Linhardt, R.A. Gross, Biomacromolecules, 21, 3197-3206, 2020.
dc.identifier.urihttps://doi.org/10.1021/acs.biomac.0c00641
dc.identifier.urihttps://hdl.handle.net/20.500.13015/5487
dc.descriptionBiomacromolecules, 21, 3197-3206
dc.descriptionNote : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
dc.description.abstractA family of poly(glycerol sebacate) (PGS) analogues were synthesized by Candida antarctica lipase B (CALB) catalysis to tailor biomaterial properties. Different fractions of glycerol (G) units in PGS were replaced by 1,8-octanediol (O) units. Poly(glycerol-1,8-octanediol-sebacate), PGOS, synthesized by CALB catalysis with a 1:3 molar ratio of G to O units has Mn and Mw values of 9500 and 92,000, respectively. PGS undergoes fiber fusion during electrospinning, and cross-linked PGS rapidly resorbs when implanted. By decreasing the molar ratio of glycerol-to-octanediol from 1:1 to 1:4, the peak melting temperature (Tm) increased from 27 to 47 °C. PGOS with 1:3 G to O units was electrospun into nanofibers without the need for a second component. The copolymer is semicrystalline and, when cross-linked, undergoes slow in vitro mass loss (3.5 ± 1.0% in 31 days) at pH 7.4 and 37 °C. Furthermore, PGOS cross-linked films have an elastic modulus of 106.1 ± 18.6 MPa, which is more than 100 times that of cross-linked PGS. New PGOS polymers showed tunable molecular weights, better thermal properties, and excellent electrospinnability. This work expanded PGS analogues’ function, making these suitable biodegradable polymers for various biomedical applications.
dc.description.urihttps://login.libproxy.rpi.edu/login?url=https://doi.org/10.1021/acs.biomac.0c00641
dc.languageen_US
dc.language.isoENG
dc.relation.ispartofThe Linhardt Research Labs Online Collection
dc.relation.ispartofRensselaer Polytechnic Institute, Troy, NY
dc.relation.urihttps://harc.rpi.edu/
dc.subjectBiology
dc.subjectChemistry and chemical biology
dc.subjectChemical and biological engineering
dc.subjectBiomedical engineering
dc.titleEnzymatic polymerization of poly(glycerol-1,8-octanediol-sebacate): versatile PGS analogs that form mono-component biodegradable fiber scaffolds
dc.typeArticle
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dcterms.isVersionOfhttps://doi.org/10.1021/acs.biomac.0c00641
dc.rights.holderIn Copyright : this Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). https://rightsstatements.org/page/InC/1.0/
dc.creator.identifierhttps://orcid.org/0000-0003-2219-5833
dc.relation.departmentThe Linhardt Research Labs.
dc.relation.departmentThe Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)


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