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dc.contributor.authorJin, Weihua
dc.contributor.authorHe, Xinyue
dc.contributor.authorZhu, Jiachen
dc.contributor.authorFang, Qiufu
dc.contributor.authorWei, Bin
dc.contributor.authorSun, Jiadong
dc.contributor.authorZhang, Wenjing
dc.contributor.authorZhang, Zhongshan
dc.contributor.authorZhang, Fuming
dc.contributor.authorLinhardt, Robert J.
dc.contributor.authorWang, Hong
dc.contributor.authorZhong, Weihong
dc.date2020
dc.date.accessioned2022-06-27T15:40:49Z
dc.date.available2022-06-27T15:40:49Z
dc.date.issued2020-11-15
dc.identifier.citationInhibition of glucuronomannan hexamer on the proliferation of lung cancer through binding with immunoglobulin G, W. Jin, X. He, J. Zhu, Q. Fang, B. Wei, J. Sun, W. Zhang, Z. Zhang, F. Zhang, R. J. Linhardt, H. Wang, W. Zhong, Carbohydrate Polymers, 248, 116785, 2020.
dc.identifier.issn1448617
dc.identifier.urihttps://doi.org/10.1016/j.carbpol.2020.116785
dc.identifier.urihttps://hdl.handle.net/20.500.13015/5492
dc.descriptionCarbohydrate Polymers, 248, 116785
dc.descriptionNote : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
dc.description.abstractThe anti-lung cancer activity of oligosaccharides derived from glucuronomannan was investigated. The inhibition of A549 cell proliferation by glucuronomannan (Gn) and its oligomers (dimer (G2), tetramer (G4) and hexamer (G6)) were concentration dependent. In vivo activities on the A549-derived tumor xenografts showed the tumor inhibition of G2, G4 and G6 were 17 %, 40 % and 46 %, respectively. Organ coefficients in nude mice showed an increase in the kidney with G4, the brain with G6, and the spleen with G6. An advanced tandem mass tag labeled proteomics approach was performed. A significant differential expression was found in 59 out of the 4371 proteins, which involved the immune system. Surface plasmon resonance (SPR) studies revealed G6 was strongly bound to immunoglobulin G. This suggests that glucuronomannan hexamer inhibits the proliferation of lung cancer through its binding to immunoglobulin.
dc.description.sponsorshipNational Natural Science Foundation of China
dc.description.urihttps://login.libproxy.rpi.edu/login?url=https://doi.org/10.1016/j.carbpol.2020.116785
dc.languageen_US
dc.language.isoENG
dc.relation.ispartofThe Linhardt Research Labs Online Collection
dc.relation.ispartofRensselaer Polytechnic Institute, Troy, NY
dc.relation.ispartofCarbohydrate Polymers
dc.relation.urihttps://harc.rpi.edu/
dc.subjectBiology
dc.subjectChemistry and chemical biology
dc.subjectChemical and biological engineering
dc.subjectBiomedical engineering
dc.titleInhibition of glucuronomannan hexamer on the proliferation of lung cancer through binding with immunoglobulin G
dc.typeArticle
dcterms.accessRightshttps://login.libproxy.rpi.edu/login?url=https://doi.org/10.1016/j.carbpol.2020.116785
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dcterms.isVersionOfhttps://doi.org/10.1016/j.carbpol.2020.116785
dc.rights.holderIn Copyright : this Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). https://rightsstatements.org/page/InC/1.0/
dc.creator.identifierhttps://orcid.org/0000-0003-2219-5833
dc.relation.departmentThe Linhardt Research Labs.
dc.relation.departmentThe Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)
rpi.description.volume248


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