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dc.contributor.authorFeng, Kun
dc.contributor.authorWei, Yun shan
dc.contributor.authorHu, Teng gen
dc.contributor.authorLinhardt, Robert J.
dc.contributor.authorZong, Min hua
dc.contributor.authorWu, Hong
dc.date2020
dc.date.accessioned2022-06-27T15:41:31Z
dc.date.available2022-06-27T15:41:31Z
dc.date.issued2020-08-01
dc.identifier.citationColon-targeted delivery systems for nutraceuticals: A review of current vehicles, evaluation methods and future prospects, K. Feng, Y.-S. Wei, T.-G. Hu, R. J. Linhardt, M.-H. Zong, H. Wu, Trends in Food Science & Technology, 102, 203-222, 2020.
dc.identifier.issn9242244
dc.identifier.urihttps://doi.org/10.1016/j.tifs.2020.05.019
dc.identifier.urihttps://hdl.handle.net/20.500.13015/5495
dc.descriptionTrends in Food Science & Technology, 102, 203-222
dc.descriptionNote : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
dc.description.abstractBackground: Advances in nutriology have suggested the colon as a superior site for nutrition absorption. Nutraceuticals, including phytochemicals, probiotics, etc., have received great attention owing to their health-promoting functionalities for colon. However, these compounds generally exhibit poor solubility or are sensitive to the harsh environment of food processing and gastrointestinal tract, thus, lowering their bioavailability and compromising their envisioned benefits. Therefore, there is a need to develop suitable delivery systems to protect active agents from these severe conditions and to maintain their functions in the colon. Scope and approaches: Colonic delivery of nutraceuticals has emerged as a new impetus for researchers interested in developing functional foods. This review presents an overview mainly about current studies relevant to different colon-targeted vehicles for nutraceuticals. The physiological conditions of colon and the corresponding principles for constructing vehicles are first reviewed to better understand the mechanisms of different vehicles. Relevant methods for evaluating the efficiency of vehicles are also summarized. Last, current limitations and the future scope for the colonic delivery of nutraceuticals are identified and addressed. Key findings and conclusions: Recently, significant progress has been made in colon-targeted delivery of nutraceuticals and different evaluation methods were applied to assess the efficacy of vehicles. However, advances in the colonic delivery of nutraceuticals are still in their early stages and multi-unit vehicles with great efficacy need to be further investigated. Furthermore, to fully mimic the real conditions of gastrointestinal tract, more systematic and precise in vitro/vivo testing should be explored to make sure that a fully function of nutraceuticals enters the colon.
dc.description.sponsorshipNational Natural Science Foundation of China
dc.description.urihttps://login.libproxy.rpi.edu/login?url=https://doi.org/10.1016/j.tifs.2020.05.019
dc.languageen_US
dc.language.isoENG
dc.relation.ispartofThe Linhardt Research Labs Online Collection
dc.relation.ispartofRensselaer Polytechnic Institute, Troy, NY
dc.relation.ispartofTrends in Food Science and Technology
dc.relation.urihttps://harc.rpi.edu/
dc.subjectBiology
dc.subjectChemistry and chemical biology
dc.subjectChemical and biological engineering
dc.subjectBiomedical engineering
dc.titleColon-targeted delivery systems for nutraceuticals: A review of current vehicles, evaluation methods and future prospects
dc.typeArticle
dcterms.accessRightshttps://login.libproxy.rpi.edu/login?url=https://doi.org/10.1016/j.tifs.2020.05.019
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dcterms.isVersionOfhttps://doi.org/10.1016/j.tifs.2020.05.019
dc.rights.holderIn Copyright : this Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). https://rightsstatements.org/page/InC/1.0/
dc.creator.identifierhttps://orcid.org/0000-0003-2219-5833
dc.relation.departmentThe Linhardt Research Labs.
dc.relation.departmentThe Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)
rpi.description.pages203-222
rpi.description.volume102


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