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dc.contributor.authorYan, Lufeng
dc.contributor.authorXia, Ke
dc.contributor.authorYu, Yanlei
dc.contributor.authorMiliakos, Anna
dc.contributor.authorChaturvedi, Sudha
dc.contributor.authorZhang, Fuming
dc.contributor.authorChen, Shiguo
dc.contributor.authorChaturvedi, Vishnu
dc.contributor.authorLinhardt, Robert J.
dc.identifier.citationUnique cell surface mannan of yeast pathogen Candida auris with selective binding to IgG, L. Yan, K. Xia, Y. Yu, A. Miliakos, S. Chaturvedi, F. Zhang, Shiguo Chen,; V. Chaturvedi,; R. J. Linhardt, ACS Infectious Diseases, 6, 1018−1031, 2020.
dc.descriptionACS Infectious Diseases, 6, 1018−1031
dc.descriptionNote : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
dc.description.abstractThe emerging, multidrug-resistant yeast pathogen Candida auris is responsible for healthcare-associated outbreaks across the globe with high mortality. The rapid spread of C. auris is linked to its successful colonization of human skin, followed by bloodstream infections. We compared glycomics and proteomics of C. auris to closely and distantly related human pathogenic yeasts, C. haemulonii and C. albicans, with the aim to understand the role of cell surface molecules in skin colonization and immune system interactions. Candida auris mannan is distinct from other pathogenic Candida species, as it is highly enriched in β-1,2-linkages. The experimental data showed that C. auris surface mannan β-1,2-linkages were important for the interactions with the immune protein IgG, found in blood and in sweat glands, and with the mannose binding lectin, found in the blood. Candida auris mannan binding to IgG was from 12- to 20-fold stronger than mannan from the more common pathogen C. albicans. The findings suggest unique C. auris mannan could be crucial for the biology and pathogenesis of this emerging pathogen.
dc.relation.ispartofThe Linhardt Research Labs Online Collection
dc.relation.ispartofRensselaer Polytechnic Institute, Troy, NY
dc.relation.ispartofACS infectious diseases
dc.subjectChemistry and chemical biology
dc.subjectChemical and biological engineering
dc.subjectBiomedical engineering
dc.titleUnique cell surface mannan of yeast pathogen Candida auris with selective binding to IgG
dc.rights.holderIn Copyright : this Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s).
dc.relation.departmentThe Linhardt Research Labs.
dc.relation.departmentThe Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)

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