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dc.contributor.authorLi, Jingmin
dc.contributor.authorQiao, Meng
dc.contributor.authorJi, Yuan
dc.contributor.authorLin, Lei
dc.contributor.authorZhang, Xing
dc.contributor.authorLinhardt, Robert J.
dc.date2020
dc.date.accessioned2022-06-27T15:42:23Z
dc.date.available2022-06-27T15:42:23Z
dc.date.issued2020-06-01
dc.identifier.citationChemical, enzymatic and biological synthesis of hyaluronic acids, J. Li, M. Qiao, Y. Ji, L. Lin, X. Zhang, R. J. Linhardt, International Journal of Biological Macromolecules, 152, 199–206, 2020.
dc.identifier.issn18790003
dc.identifier.issn1418130
dc.identifier.urihttps://doi.org/10.1016/j.ijbiomac.2020.02.214
dc.identifier.urihttps://hdl.handle.net/20.500.13015/5510
dc.descriptionInternational Journal of Biological Macromolecules, 152, 199–206
dc.descriptionNote : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
dc.description.abstractHyaluronic acid (HA) is a major glycosaminoglycan, a family of structurally complex, linear, anionic hetero-co-polysaccharides. HA is important in various anatomical structures including the eyes, joints, heart and myriad intricate tissues, and is currently widely used in the therapeutics and cosmetics areas. The synthesis of HA of well-defined and uniform chain lengths is of major interest for the development of safer and more reliable drugs and to gain a better understanding of its structure-activity relationships. However, HA has received less attention from the synthetic carbohydrate community compared with other members of the glycosaminoglycan family. In this review, we examine the remarkable progress that has been made in the chemical and chemoenzymatic synthesis of HA, providing a broad spectrum of options to access HA of well controlled chain lengths.
dc.description.sponsorshipNational Institutes of Health
dc.description.urihttps://login.libproxy.rpi.edu/login?url=https://doi.org/10.1016/j.ijbiomac.2020.02.214
dc.languageen_US
dc.language.isoENG
dc.relation.ispartofThe Linhardt Research Labs Online Collection
dc.relation.ispartofRensselaer Polytechnic Institute, Troy, NY
dc.relation.ispartofInternational Journal of Biological Macromolecules
dc.relation.urihttps://harc.rpi.edu/
dc.subjectBiology
dc.subjectChemistry and chemical biology
dc.subjectChemical and biological engineering
dc.subjectBiomedical engineering
dc.titleChemical, enzymatic and biological synthesis of hyaluronic acids
dc.typeArticle
dcterms.accessRightshttps://login.libproxy.rpi.edu/login?url=https://doi.org/10.1016/j.ijbiomac.2020.02.214
dcterms.isPartOfJournal
dcterms.isVersionOfhttps://doi.org/10.1016/j.ijbiomac.2020.02.214
dc.rights.holderIn Copyright : this Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). https://rightsstatements.org/page/InC/1.0/
dc.creator.identifierhttps://orcid.org/0000-0003-2219-5833
dc.relation.departmentThe Linhardt Research Labs.
dc.relation.departmentThe Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)
rpi.description.pages199-206
rpi.description.volume152


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