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dc.contributor.authorLin, Lei
dc.contributor.authorQiao, Meng
dc.contributor.authorZhang, Xing
dc.contributor.authorLinhardt, Robert J.
dc.date2020
dc.date.accessioned2022-06-27T15:42:24Z
dc.date.available2022-06-27T15:42:24Z
dc.date.issued2020-02-15
dc.identifier.citationSite-selective reactions for the synthesis of glycoconjugates in polysaccharide vaccine development, L. Lin, M. Qiao, X. Zhang, R. J. Linhardt, Carbohydrate Polymers, 230, 115643, 2020.
dc.identifier.issn1448617
dc.identifier.urihttps://doi.org/10.1016/j.carbpol.2019.115643
dc.identifier.urihttps://hdl.handle.net/20.500.13015/5520
dc.descriptionCarbohydrate Polymers, 230, 115643
dc.descriptionNote : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
dc.description.abstractCarbohydrates are often found linked to lipids or proteins, to form glycoconjugates such as glycolipids, glycoproteins and proteoglycans. These glycoconjugates play important biological roles, involving cell-cell recognition, inflammation, immune response, tumor metastasis and in viral/bacterial/parasitic infections. However, it is difficult to obtain these naturally occurring glycoconjugates as they are often heterogeneous compositions, which causes batch-to-batch variability of structure and activity often leading an incomplete understanding of their mechanism of action. Thus, the efficient preparation of synthetic glycoconjugates, possessing well-defined compositions and reproducible biological properties is highly desirable. In the present review, we summarize the advances in site-selective approaches for glycoconjugate synthesis and, in particular, the preparation of polysaccharide vaccines.
dc.description.sponsorshipNational Institutes of Health
dc.description.urihttps://login.libproxy.rpi.edu/login?url=https://doi.org/10.1016/j.carbpol.2019.115643
dc.languageen_US
dc.language.isoENG
dc.relation.ispartofThe Linhardt Research Labs Online Collection
dc.relation.ispartofRensselaer Polytechnic Institute, Troy, NY
dc.relation.ispartofCarbohydrate Polymers
dc.relation.urihttps://harc.rpi.edu/
dc.subjectBiology
dc.subjectChemistry and chemical biology
dc.subjectChemical and biological engineering
dc.subjectBiomedical engineering
dc.titleSite-selective reactions for the synthesis of glycoconjugates in polysaccharide vaccine development
dc.typeArticle
dcterms.accessRightshttps://login.libproxy.rpi.edu/login?url=https://doi.org/10.1016/j.carbpol.2019.115643
dcterms.isPartOfJournal
dcterms.isVersionOfhttps://doi.org/10.1016/j.carbpol.2019.115643
dc.rights.holderIn Copyright : this Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). https://rightsstatements.org/page/InC/1.0/
dc.creator.identifierhttps://orcid.org/0000-0003-2219-5833
dc.relation.departmentThe Linhardt Research Labs.
dc.relation.departmentThe Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)
rpi.description.volume230


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