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dc.contributor.authorMikael, Paiyz E.
dc.contributor.authorUdangawa, Ranodhi
dc.contributor.authorSorci, Mirco
dc.contributor.authorCress, Brady
dc.contributor.authorShtein, Zvi
dc.contributor.authorBelfort, Georges
dc.contributor.authorShoseyov, Oded
dc.contributor.authorDordick, Jonathan S.
dc.contributor.authorLinhardt, Robert J.
dc.identifier.citationProduction and characterization of recombinant collagen binding resilin nanocomposite for regenerative medicine applications, P. E. Mikael, R. Udangawa, M. Sorci, B. Cress, Z. Shtein, G. Belfort, O. Shoseyov, J. S. Dordick, R. J. Linhardt, Regenerative Engineering and Translational Medicine, 5, 362–372, 2019.
dc.descriptionRegenerative Engineering and Translational Medicine, 5, 362–372
dc.descriptionNote : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
dc.description.abstractDevelopment of mechanically stable and multifunctional biomaterials for sensing, repair, and regeneration applications is of great importance. Herein, we investigate the potential of recombinant resilin-like (Res) nanocomposite elastomer as a template biomaterial for regenerative devices such as adhesive bandages or films, electrospun fibers, screws, sutures, and drug delivery vehicles. Exon I (Rec1) from the native resilin gene of Drosophila (CG15920) was fused with collagen-binding domain (ColBD) from Clostridium histolyticum and expressed in Komagataella pastoris (formerly Pichia pastoris). The 100% binding of Resilin-ColBD (Res-ColBD) to collagen I was shown at a 1:1 ratio by mass. Atomic force microscopy results in force mode show a bimodal profile for the ColBD-binding interactions. Moreover, based on the force-volume map, Res-ColBD adhesion to collagen was statistically significantly higher than resilin without ColBD.
dc.description.sponsorshipNational Institutes of Health
dc.relation.ispartofThe Linhardt Research Labs Online Collection
dc.relation.ispartofRensselaer Polytechnic Institute, Troy, NY
dc.relation.ispartofRegenerative Engineering and Translational Medicine
dc.subjectChemistry and chemical biology
dc.subjectChemical and biological engineering
dc.subjectBiomedical engineering
dc.titleProduction and characterization of recombinant collagen binding resilin nanocomposite for regenerative medicine applications
dc.rights.holderIn Copyright : this Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s).
dc.relation.departmentThe Linhardt Research Labs.
dc.relation.departmentThe Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)

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