Biology; Chemistry and chemical biology; Chemical and biological engineering; Biomedical engineering
In Copyright : this Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). https://rightsstatements.org/page/InC/1.0/;
Heparin Contamination and Issues Related to Raw Materials and Controls, Y. Zhu, F. Zhang, R. J. Linhardt, In The Science and Regulations of Naturally Derived Complex Drugs, Sasisekharan, R., Lee, S.L., Rosenberg, A., Walker, L.A. (Eds.), AAPS Advances in the Pharmaceutical Sciences Series 39, Chapter 11, pp 191-206, Springer Nature, NY, 2019.
Heparin is a century-old polypharmacological drug critical for the practice of modern medicine. In recent years, there have been a number of issues arising in the preparation of heparin from food animal tissues. The most severe problem was the adulteration of porcine intestinal heparin with a toxic semisynthetic look-alike polysaccharide, oversulfated chondroitin sulfate, which resulted in a number of patient deaths. Since this crisis, regulatory and analytical control of heparin has been markedly improved; new challenges in securing the heparin supply chain have prompted the reintroduction of heparins from new animal sources . In future, the introduction of bioengineered heparins might offer better approaches for securing this critical drug.;
AAPS Advances in the Pharmaceutical Sciences Series 39, Chapter 11, pp 191-206, Springer Nature, NY; Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
The Linhardt Research Labs.; The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS);
The Linhardt Research Labs Online Collection; Rensselaer Polytechnic Institute, Troy, NY; AAPS Advances in the Pharmaceutical Sciences Series; https://harc.rpi.edu/;