Show simple item record

dc.contributor.authorZhu, Yuanyuan
dc.contributor.authorZhang, Fuming
dc.contributor.authorLinhardt, Robert J.
dc.contributor.authorLee, R.
dc.contributor.authorRosenberg, S.L.
dc.contributor.authorWalker, A.
dc.identifier.citationHeparin Contamination and Issues Related to Raw Materials and Controls, Y. Zhu, F. Zhang, R. J. Linhardt, In The Science and Regulations of Naturally Derived Complex Drugs, Sasisekharan, R., Lee, S.L., Rosenberg, A., Walker, L.A. (Eds.), AAPS Advances in the Pharmaceutical Sciences Series 39, Chapter 11, pp 191-206, Springer Nature, NY, 2019.
dc.descriptionAAPS Advances in the Pharmaceutical Sciences Series 39, Chapter 11, pp 191-206, Springer Nature, NY
dc.descriptionNote : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
dc.description.abstractHeparin is a century-old polypharmacological drug critical for the practice of modern medicine. In recent years, there have been a number of issues arising in the preparation of heparin from food animal tissues. The most severe problem was the adulteration of porcine intestinal heparin with a toxic semisynthetic look-alike polysaccharide, oversulfated chondroitin sulfate, which resulted in a number of patient deaths. Since this crisis, regulatory and analytical control of heparin has been markedly improved; new challenges in securing the heparin supply chain have prompted the reintroduction of heparins from new animal sources . In future, the introduction of bioengineered heparins might offer better approaches for securing this critical drug.
dc.relation.ispartofThe Linhardt Research Labs Online Collection
dc.relation.ispartofRensselaer Polytechnic Institute, Troy, NY
dc.relation.ispartofAAPS Advances in the Pharmaceutical Sciences Series
dc.subjectChemistry and chemical biology
dc.subjectChemical and biological engineering
dc.subjectBiomedical engineering
dc.titleHeparin Contamination and Issues Related to Raw Materials and Controls
dc.typeBook chapter
dcterms.isPartOfBook Series
dc.rights.holderIn Copyright : this Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s).
dc.relation.departmentThe Linhardt Research Labs.
dc.relation.departmentThe Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)

Files in this item


There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record