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dc.contributor.authorZhu, Yuanyuan
dc.contributor.authorZhang, Fuming
dc.contributor.authorLinhardt, Robert J.
dc.contributor.authorSasisekharan,
dc.contributor.authorLee, R.
dc.contributor.authorRosenberg, S.L.
dc.contributor.authorWalker, A.
dc.date2019
dc.date.accessioned2022-06-27T15:47:40Z
dc.date.available2022-06-27T15:47:40Z
dc.date.issued2019-01-01
dc.identifier.citationHeparin Contamination and Issues Related to Raw Materials and Controls, Y. Zhu, F. Zhang, R. J. Linhardt, In The Science and Regulations of Naturally Derived Complex Drugs, Sasisekharan, R., Lee, S.L., Rosenberg, A., Walker, L.A. (Eds.), AAPS Advances in the Pharmaceutical Sciences Series 39, Chapter 11, pp 191-206, Springer Nature, NY, 2019.
dc.identifier.issn2210738X
dc.identifier.issn22107371
dc.identifier.urihttps://doi.org/10.1007/978-3-030-11751-1_11
dc.identifier.urihttps://hdl.handle.net/20.500.13015/5545
dc.descriptionAAPS Advances in the Pharmaceutical Sciences Series 39, Chapter 11, pp 191-206, Springer Nature, NY
dc.descriptionNote : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
dc.description.abstractHeparin is a century-old polypharmacological drug critical for the practice of modern medicine. In recent years, there have been a number of issues arising in the preparation of heparin from food animal tissues. The most severe problem was the adulteration of porcine intestinal heparin with a toxic semisynthetic look-alike polysaccharide, oversulfated chondroitin sulfate, which resulted in a number of patient deaths. Since this crisis, regulatory and analytical control of heparin has been markedly improved; new challenges in securing the heparin supply chain have prompted the reintroduction of heparins from new animal sources . In future, the introduction of bioengineered heparins might offer better approaches for securing this critical drug.
dc.description.urihttps://login.libproxy.rpi.edu/login?url=https://doi.org/10.1007/978-3-030-11751-1_11
dc.languageen_US
dc.language.isoENG
dc.relation.ispartofThe Linhardt Research Labs Online Collection
dc.relation.ispartofRensselaer Polytechnic Institute, Troy, NY
dc.relation.ispartofAAPS Advances in the Pharmaceutical Sciences Series
dc.relation.urihttps://harc.rpi.edu/
dc.subjectBiology
dc.subjectChemistry and chemical biology
dc.subjectChemical and biological engineering
dc.subjectBiomedical engineering
dc.titleHeparin Contamination and Issues Related to Raw Materials and Controls
dc.typeBook chapter
dcterms.accessRightshttps://login.libproxy.rpi.edu/login?url=https://doi.org/10.1007/978-3-030-11751-1_11
dcterms.isPartOfBook Series
dcterms.isVersionOfhttps://doi.org/10.1007/978-3-030-11751-1_11
dc.rights.holderIn Copyright : this Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). https://rightsstatements.org/page/InC/1.0/
dc.creator.identifierhttps://orcid.org/0000-0003-2219-5833
dc.relation.departmentThe Linhardt Research Labs.
dc.relation.departmentThe Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)
rpi.description.pages191-206
rpi.description.volume32


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