| dc.contributor.author | Zhang, Xing | |
| dc.contributor.author | Dickinson, Demetria M. | |
| dc.contributor.author | Lin, Lei | |
| dc.contributor.author | Suflita, Matthew | |
| dc.contributor.author | Baytas, Sultan | |
| dc.contributor.author | Linhardt, Robert J. | |
| dc.date | 2019 | |
| dc.date.accessioned | 2022-06-27T15:47:40Z | |
| dc.date.available | 2022-06-27T15:47:40Z | |
| dc.date.issued | 2019-03-28 | |
| dc.identifier.citation | Chemoenzymatic synthesis of heparan sulfate tetrasaccharide from a N-acetyl-α-D-glucosamine-O-methylglycoside acceptor, X. Zhang, D. M. Dickinson, L. Lin, M. Suflita, S. Baytas, R. J. Linhardt, Tetrahedron Letters, 60, 911–915, 2019. | |
| dc.identifier.issn | 18733581 | |
| dc.identifier.issn | 404039 | |
| dc.identifier.uri | https://doi.org/10.1016/j.tetlet.2019.02.036 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.13015/5554 | |
| dc.description | Tetrahedron Letters, 60, 911–915 | |
| dc.description | Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform. | |
| dc.description.abstract | Heparan sulfate tetrasaccharide 2 was efficiently prepared in seven steps through chemoenzymatic synthesis. A monosaccharide 5, N-acetyl-α-d-glucosamine- O-methylglycoside (GlcNAc-OMe), was successfully used as an acceptor in a heparosan synthase (pmHS2)-catalyzed glycosylation reaction. This avoided the multi-step synthesis of a more complex disaccharide acceptor 3, greatly simplifying the route to tetrasaccharide target 2. This approach provides a critical tetrasaccharide intermediate for subsequent chemoenzymatic transformation to fondaparinux and its analogues. | |
| dc.description.sponsorship | National Institutes of Health | |
| dc.description.uri | https://login.libproxy.rpi.edu/login?url=https://doi.org/10.1016/j.tetlet.2019.02.036 | |
| dc.language | en_US | |
| dc.language.iso | ENG | |
| dc.relation.ispartof | The Linhardt Research Labs Online Collection | |
| dc.relation.ispartof | Rensselaer Polytechnic Institute, Troy, NY | |
| dc.relation.ispartof | Tetrahedron Letters | |
| dc.relation.uri | https://harc.rpi.edu/ | |
| dc.subject | Biology | |
| dc.subject | Chemistry and chemical biology | |
| dc.subject | Chemical and biological engineering | |
| dc.subject | Biomedical engineering | |
| dc.title | Chemoenzymatic synthesis of heparan sulfate tetrasaccharide from a N-acetyl-α-D-glucosamine-O-methylglycoside acceptor | |
| dc.type | Article | |
| dcterms.accessRights | https://login.libproxy.rpi.edu/login?url=https://doi.org/10.1016/j.tetlet.2019.02.036 | |
| dcterms.isPartOf | Journal | |
| dcterms.isVersionOf | https://doi.org/10.1016/j.tetlet.2019.02.036 | |
| dc.rights.holder | In Copyright : this Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). https://rightsstatements.org/page/InC/1.0/ | |
| dc.creator.identifier | https://orcid.org/0000-0003-2219-5833 | |
| dc.relation.department | The Linhardt Research Labs. | |
| dc.relation.department | The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS) | |
| rpi.description.pages | 911-915 | |
| rpi.description.volume | 60 | |
