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dc.contributor.authorPeng, X.
dc.contributor.authorPeng, Y.
dc.contributor.authorHan, B.
dc.contributor.authorLiu, W.
dc.contributor.authorZhang, F.
dc.contributor.authorLinhardt, Robert J.
dc.identifier.citationIO4-- stimulated crosslinking of catechol-conjugated hydroxyethylchitosan as a tissue adhesive, X. Peng, Y. Peng, B. Han, W. Liu, F. Zhang, R. J Linhardt, Journal of Biomedical Materials Research Part B: Applied Biomaterials, 107B, 582-593, 2019.
dc.descriptionJournal of Biomedical Materials Research Part B: Applied Biomaterials, 107B, 582-593
dc.descriptionNote : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
dc.description.abstractCatechol-functionalized polymers are of particular interest because of their strong water-resistant adhesive properties. Hydroxymethyl chitosan (HECTS) has been used as an implantable biomaterial having good water solubility, biodegradability and biocompatibility. Here, hydrocaffeic acid (HCA) grafted HECTS (HCA-g-HECTS) was prepared through carbodiimide coupling and the tethered catechol underwent periodate (urn:x-wiley:15524973:media:jbmb34150:jbmb34150-math-0003)-stimulated mono and double cross-linking with genipin. The gelation time of these cross-linked HCA-g-HECTS hydrogels decreased with increasing molar ratio of cross-linker to grafted catechol group, increasing temperature, or the addition of genipin. Under the same molar ratio of cross-linker to catechol, urn:x-wiley:15524973:media:jbmb34150:jbmb34150-math-0004-induced cross-linked HCA-g-HECTS hydrogels exhibited much stronger storage modulus and temperature stability than hydrogels made by Fe3+-triggered cross-linking. The urn:x-wiley:15524973:media:jbmb34150:jbmb34150-math-0005-stimulated HCA-g-HECTS hydrogels were biocompatible on a cellular level when the molar ratio of urn:x-wiley:15524973:media:jbmb34150:jbmb34150-math-0006 to catechol group was less than 0.5:1. The hydrogels prepared with a 0.125:1 molar ratio of urn:x-wiley:15524973:media:jbmb34150:jbmb34150-math-0007 to catechol group exhibited high adhesion strength of 73.56 kPa against wet rat skin, and a higher adhesion strength than sutures in a rat wound closure model. This biocompatible urn:x-wiley:15524973:media:jbmb34150:jbmb34150-math-0008-stimulated HCA-g-HECTS hydrogel may represent a promising new tissue adhesive.
dc.relation.ispartofThe Linhardt Research Labs Online Collection
dc.relation.ispartofRensselaer Polytechnic Institute, Troy, NY
dc.subjectChemistry and chemical biology
dc.subjectChemical and biological engineering
dc.subjectBiomedical engineering
dc.titleIO4-- stimulated crosslinking of catechol-conjugated hydroxyethylchitosan as a tissue adhesive
dc.rights.holderIn Copyright : this Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s).
dc.relation.departmentThe Linhardt Research Labs.
dc.relation.departmentThe Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)

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