Biology; Chemistry and chemical biology; Chemical and biological engineering; Biomedical engineering
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Non-anticoagulant low molecular weight heparins for pharmaceutical applications, Y. Ouyang, Y. Yu, F. Zhang, J. Chen, X. Han, K. Xia, Y. Yao, Z. Zhang, R. J. Linhardt, Journal of Medicinal Chemistry, 62, 1067-1073, 2019.
Heparin is a polypharmacological agent with anticoagulant activity. Periodate oxidation of the nonsulfated glucuronic acid residue results in non-anticoagulant heparin derivative (NACH) of reduced molecular weight. Similar treatment of a low molecular weight heparin, dalteparin, also removes its anticoagulant activity, affording a second heparin derivative (D-NACH). A full structural characterization of these two derivatives reveals their structural differences. SPR studies display their ability to bind to several important heparin-binding proteins, suggesting potential new therapeutic applications.;
Journal of Medicinal Chemistry, 62, 1067-1073; Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
The Linhardt Research Labs.; The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS);
The Linhardt Research Labs Online Collection; Rensselaer Polytechnic Institute, Troy, NY; Journal of Medicinal Chemistry; https://harc.rpi.edu/;