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Non-anticoagulant low molecular weight heparins for pharmaceutical applications

dc.contributor.authorOuyang, Yilan
dc.contributor.authorYu, Yanlei
dc.contributor.authorZhang, Fuming
dc.contributor.authorChen, Jianle
dc.contributor.authorHan, Xiaorui
dc.contributor.authorXia, Ke
dc.contributor.authorYao, Yiming
dc.contributor.authorZhang, Zhenqing
dc.contributor.authorLinhardt, Robert J.
dc.date2019
dc.date.accessioned2022-06-27T15:48:05Z
dc.date.available2022-06-27T15:48:05Z
dc.date.issued2019-01-24
dc.identifier.citationNon-anticoagulant low molecular weight heparins for pharmaceutical applications, Y. Ouyang, Y. Yu, F. Zhang, J. Chen, X. Han, K. Xia, Y. Yao, Z. Zhang, R. J. Linhardt, Journal of Medicinal Chemistry, 62, 1067-1073, 2019.
dc.identifier.issn15204804
dc.identifier.issn222623
dc.identifier.urihttps://doi.org/10.1021/acs.jmedchem.8b01551
dc.identifier.urihttps://hdl.handle.net/20.500.13015/5561
dc.descriptionJournal of Medicinal Chemistry, 62, 1067-1073
dc.descriptionNote : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
dc.description.abstractHeparin is a polypharmacological agent with anticoagulant activity. Periodate oxidation of the nonsulfated glucuronic acid residue results in non-anticoagulant heparin derivative (NACH) of reduced molecular weight. Similar treatment of a low molecular weight heparin, dalteparin, also removes its anticoagulant activity, affording a second heparin derivative (D-NACH). A full structural characterization of these two derivatives reveals their structural differences. SPR studies display their ability to bind to several important heparin-binding proteins, suggesting potential new therapeutic applications.
dc.description.sponsorshipNational Institutes of Health
dc.description.urihttps://login.libproxy.rpi.edu/login?url=https://doi.org/10.1021/acs.jmedchem.8b01551
dc.languageen_US
dc.language.isoENG
dc.relation.ispartofThe Linhardt Research Labs Online Collection
dc.relation.ispartofRensselaer Polytechnic Institute, Troy, NY
dc.relation.ispartofJournal of Medicinal Chemistry
dc.relation.urihttps://harc.rpi.edu/
dc.subjectBiology
dc.subjectChemistry and chemical biology
dc.subjectChemical and biological engineering
dc.subjectBiomedical engineering
dc.titleNon-anticoagulant low molecular weight heparins for pharmaceutical applications
dc.typeArticle
dcterms.accessRightshttps://login.libproxy.rpi.edu/login?url=https://doi.org/10.1021/acs.jmedchem.8b01551
dcterms.isPartOfJournal
dcterms.isVersionOfhttps://doi.org/10.1021/acs.jmedchem.8b01551
dc.rights.holderIn Copyright : this Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). https://rightsstatements.org/page/InC/1.0/
dc.creator.identifierhttps://orcid.org/0000-0003-2219-5833
dc.relation.departmentThe Linhardt Research Labs.
dc.relation.departmentThe Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)
rpi.description.pages1067-1073
rpi.description.volume62


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