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dc.contributor.authorLi, Junhui
dc.contributor.authorLi, Shan
dc.contributor.authorLiu, Shanshan
dc.contributor.authorWei, Chaoyang
dc.contributor.authorYan, Lufeng
dc.contributor.authorDing, Tian
dc.contributor.authorLinhardt, Robert J.
dc.contributor.authorLiu, Donghong
dc.contributor.authorYe, Xingqian
dc.contributor.authorChen, Shiguo
dc.identifier.citationPectic oligosaccharides hydrolyzed from citrus canning processing water by Fenton reaction and their antiproliferation potentials, S. Liu, S. Li, D. Liu, L. Yan, R.J. Linhardt, T. Ding, X. Ye, L. Junhui, C. Wei, S. Chen, International Journal of Biological Macromolecules,124, 1025–1032, 2019.
dc.descriptionInternational Journal of Biological Macromolecules, 124, 1025–1032
dc.descriptionNote : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
dc.description.abstractCitrus canning processing water contains a valuable and renewable source of biopolymers and bioactive compounds including pectic polysaccharides. Upgrading these processing wastes can not only alleviate environmental pollution but also add value to the commodity's production. In a previous study we recovered pectic polysaccharides from citrus canning processing water. In the present study, pectic polysaccharides recycled from citrus canning processing water was depolymerized by an optimized Fenton system. The hydrolyzate was fractionated via size-exclusion chromatography into six fractions: 500 Da < LMP1 < 3 kDa; 3 kDa < LMP2 < 5 kDa; 5 kDa < LMP3 < 12 kDa; 12 kDa < LMP4 < 25 kDa; 25 kDa < LMP5 < 100 kDa and LMP6 > 10 wDa. Structure analyses showed that LMP1 were homogalacturonans-enriched non-esterified polysaccharides. While LMP2 contained both HG and rhamnogalacturonan-I (RG-I). Further antitumor assay showed that in comparison with the native pectic polysaccharide with moderate antitumor activity, both LMP1 and LMP2 possessed significant antitumor activity, while the inhibitory effect of LMP1 was higher than that of LMP2, suggesting that the biological properties of LMPs was influenced by structural characteristics, including molecular weight and monosaccharide composition.
dc.description.sponsorshipZhejiang Province Public Welfare Technology Application Research Project
dc.relation.ispartofThe Linhardt Research Labs Online Collection
dc.relation.ispartofRensselaer Polytechnic Institute, Troy, NY
dc.relation.ispartofInternational Journal of Biological Macromolecules
dc.subjectChemistry and chemical biology
dc.subjectChemical and biological engineering
dc.subjectBiomedical engineering
dc.titlePectic oligosaccharides hydrolyzed from citrus canning processing water by Fenton reaction and their antiproliferation potentials
dc.rights.holderIn Copyright : this Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s).
dc.relation.departmentThe Linhardt Research Labs.
dc.relation.departmentThe Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)

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