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dc.contributor.authorLi, Shan
dc.contributor.authorLi, Junhui
dc.contributor.authorMao, Guizhu
dc.contributor.authorWu, Tiantian
dc.contributor.authorLin, Dingbo
dc.contributor.authorHu, Yaqin
dc.contributor.authorYe, Xingqian
dc.contributor.authorTian, Ding
dc.contributor.authorChai, Wengang
dc.contributor.authorLinhardt, Robert J.
dc.contributor.authorChen, Shiguo
dc.date2019
dc.date.accessioned2022-06-27T15:48:06Z
dc.date.available2022-06-27T15:48:06Z
dc.date.issued2019-03-01
dc.identifier.citationFucosylated chondroitin sulfate from Isostichopus badionotus alleviates metabolic syndromes and gut microbiota dysbiosis induced by high-fat and high-fructose diet, S. Li, J. Li, G. Mao, T. Wu, D. Lin, Y. Hu, X. Ye, D. Tian, W. Chai, R.J. Linhardt, S. Chen, International Journal of Biological Macromolecules,124, 377–388, 2019
dc.identifier.issn18790003
dc.identifier.issn1418130
dc.identifier.urihttps://doi.org/10.1016/j.ijbiomac.2018.11.167
dc.identifier.urihttps://hdl.handle.net/20.500.13015/5569
dc.descriptionInternational Journal of Biological Macromolecules,124, 377–388
dc.descriptionNote : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
dc.description.abstractFucosylated chondroitin sulfate from Isostichopus badionotus (fCS-Ib) is a kind of sulfated polysaccharides with well-repeated structure. In our former publications, fCS-Ib has been reported to be a functional food ingredient with hypoglycemic and antilipemic activities. However, there is no systematic study to investigate the effects of fCS-Ib on metabolic syndromes. In the present study, C57BL/6 mice fed on a high-fat and high sucrose diet (HFSD) for 6 weeks was used to cause metabolic syndromes. The final results showed that fCS-Ib alleviated obesity, hyperlipidemia, hyperglycemia, inflammation, liver steatosis, and adipocyte hypertrophy caused by HFSD. Meanwhile, fCS-Ib showed powerful effects on moderating gut microbiota dysbiosis in the HFSD-fed mice. Supplement of fCS-Ib could reduce ratio of Firmicutes to Bacteroidetes by decreasing abundance of Lachnospiraceae and Allobaculum while increasing abundance of Porphyromonadaceae, Barnesiella, and Bacteroides. Our results showed that fCS-Ib could be further developed as a potential pharmaceutical agent to prevent metabolic syndromes and gut microbiota dysbiosis.
dc.description.urihttps://login.libproxy.rpi.edu/login?url=https://doi.org/10.1016/j.ijbiomac.2018.11.167
dc.languageen_US
dc.language.isoENG
dc.relation.ispartofThe Linhardt Research Labs Online Collection
dc.relation.ispartofRensselaer Polytechnic Institute, Troy, NY
dc.relation.ispartofInternational Journal of Biological Macromolecules
dc.relation.urihttps://harc.rpi.edu/
dc.subjectBiology
dc.subjectChemistry and chemical biology
dc.subjectChemical and biological engineering
dc.subjectBiomedical engineering
dc.titleFucosylated chondroitin sulfate from Isostichopus badionotus alleviates metabolic syndromes and gut microbiota dysbiosis induced by high-fat and high-fructose diet
dc.typeArticle
dcterms.accessRightshttps://login.libproxy.rpi.edu/login?url=https://doi.org/10.1016/j.ijbiomac.2018.11.167
dcterms.isPartOfJournal
dcterms.isVersionOfhttps://doi.org/10.1016/j.ijbiomac.2018.11.167
dc.rights.holderIn Copyright : this Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). https://rightsstatements.org/page/InC/1.0/
dc.creator.identifierhttps://orcid.org/0000-0003-2219-5833
dc.relation.departmentThe Linhardt Research Labs.
dc.relation.departmentThe Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)
rpi.description.pages377-388
rpi.description.volume124


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