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dc.contributor.authorWei, Chaoyang
dc.contributor.authorZhang, Yu
dc.contributor.authorHe, Liang
dc.contributor.authorCheng, Junwen
dc.contributor.authorLi, Junhui
dc.contributor.authorTao, Wenyang
dc.contributor.authorMao, Guizhu
dc.contributor.authorZhang, Hua
dc.contributor.authorLinhardt, Robert J.
dc.contributor.authorYe, Xingqian
dc.contributor.authorChen, Shiguo
dc.date2019
dc.date.accessioned2022-06-27T15:51:33Z
dc.date.available2022-06-27T15:51:33Z
dc.date.issued2019-01-01
dc.identifier.citationStructural characterization and anti-proliferative activities of partially degraded polysaccharides from peach gum, C. Wei, Y. Zhang, L. He, J. Cheng, J. Li, W. Tao, G. Mao, H. Zhang, R.J. Linhardt, X. Ye, S. Chen, Carbohydrate Polymers, 203, 193-202, 2019.
dc.identifier.issn1448617
dc.identifier.urihttps://doi.org/10.1016/j.carbpol.2018.09.029
dc.identifier.urihttps://hdl.handle.net/20.500.13015/5573
dc.descriptionCarbohydrate Polymers, 203, 193-202
dc.descriptionNote : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
dc.description.abstractLP100R, LP10R and LP5R were isolated from peach gum by ultrafiltration. They were identified as AG II arabinogalactans composed of mannose, rhamnose, glucuronic acid, galactose, xylose and arabinose, which had a β-d-(1→6)-galactan backbone and were branched at O-3 and O-4. LP100R, LP10R and LP5R exist in a spherical conformation with the molecular weight of 8.50 × 104 g/mol, 4.77 × 104 g/mol and 2.40 × 104 g/mol, respectively. The binding affinities of LP fractions to galectin-3 (Gal-3) were 0.77 μM for LP100R, 2.88 μM for LP10R and 5.15 μM for LP5R, respectively. Meanwhile, an anti-proliferative assay revealed that LP100R possessed higher anti-proliferative activity against HepG2 cells (IC50, 4.5 mg/mL) and MCF-7 cells (IC50, 0.43 mg/mL) than did LP10R and LP5R, which were in accordance with their binding affinities to galectin-3. Therefore, LP fractions (especially LP100R) might exert the anti-tumor activity by directly inhibiting the Gal-3 mediated proliferation of cancer cells.
dc.description.sponsorshipNational Natural Science Foundation of China
dc.description.urihttps://login.libproxy.rpi.edu/login?url=https://doi.org/10.1016/j.carbpol.2018.09.029
dc.languageen_US
dc.language.isoENG
dc.relation.ispartofThe Linhardt Research Labs Online Collection
dc.relation.ispartofRensselaer Polytechnic Institute, Troy, NY
dc.relation.ispartofCarbohydrate Polymers
dc.relation.urihttps://harc.rpi.edu/
dc.subjectBiology
dc.subjectChemistry and chemical biology
dc.subjectChemical and biological engineering
dc.subjectBiomedical engineering
dc.titleStructural characterization and anti-proliferative activities of partially degraded polysaccharides from peach gum
dc.typeArticle
dcterms.accessRightshttps://login.libproxy.rpi.edu/login?url=https://doi.org/10.1016/j.carbpol.2018.09.029
dcterms.isPartOfJournal
dcterms.isVersionOfhttps://doi.org/10.1016/j.carbpol.2018.09.029
dc.rights.holderIn Copyright : this Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). https://rightsstatements.org/page/InC/1.0/
dc.creator.identifierhttps://orcid.org/0000-0003-2219-5833
dc.relation.departmentThe Linhardt Research Labs.
dc.relation.departmentThe Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)
rpi.description.pages193-202
rpi.description.volume203


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