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dc.contributor.authorOuyang, Yilan
dc.contributor.authorHan, Xiaorui
dc.contributor.authorYu, Yanlei
dc.contributor.authorChen, Jianle
dc.contributor.authorFu, Li
dc.contributor.authorZhang, Fuming
dc.contributor.authorLinhardt, Robert J.
dc.contributor.authorFareed, Jawed
dc.contributor.authorHoppensteadt, Debra
dc.contributor.authorJeske, Walter
dc.contributor.authorKouta, Ahmed
dc.contributor.authorZhang, Zhenqing
dc.contributor.authorXia, Ke
dc.identifier.citationChemometric analysis of porcine, bovine and ovine heparins, Y. Ouyang, X. Han, Y. Yu, J. Chen, F. Zhang, R. J. Linhardt, J. Fareed, D. Hoppensteadt, W. Jeske, A. Kouta, Z. Zhang, K. Xia, Journal of Pharmaceutical and Biomedical Analysis, 164, 345–352, 2019.
dc.descriptionJournal of Pharmaceutical and Biomedical Analysis, 164, 345–352
dc.descriptionNote : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
dc.description.abstractHeparin is a polysaccharide anticoagulant drug isolated from animal tissues. There have been concerns on the safety and security of the heparin supply chain since 2007-8 when a contamination crisis led to its disruption. The current study applies a suite of modern analytical techniques to porcine, bovine and ovine intestinal mucosal heparins. These techniques include structural analysis by nuclear magnetic resonance spectrometry, disaccharide compositional analysis, bottom-up analysis of tetrasaccharides corresponding to heparin's antithrombin III binding site. Chemometric analysis was then applied to understand how these structural differences to predict the animal/tissue source of heparin and to help detect blending of heparins from various sources.
dc.description.sponsorshipNational Institutes of Health
dc.relation.ispartofThe Linhardt Research Labs Online Collection
dc.relation.ispartofRensselaer Polytechnic Institute, Troy, NY
dc.relation.ispartofJournal of Pharmaceutical and Biomedical Analysis
dc.subjectChemistry and chemical biology
dc.subjectChemical and biological engineering
dc.subjectBiomedical engineering
dc.titleChemometric analysis of porcine, bovine and ovine heparins
dc.rights.holderIn Copyright : this Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s).
dc.relation.departmentThe Linhardt Research Labs.
dc.relation.departmentThe Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)

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