Show simple item record

dc.contributor.authorLi, S.
dc.contributor.authorLi, J.
dc.contributor.authorMao, G.
dc.contributor.authorWu, T.
dc.contributor.authorHu, Y.
dc.contributor.authorYe, X.
dc.contributor.authorTian, D.
dc.contributor.authorLinhardt, Robert J.
dc.contributor.authorChen, S.
dc.identifier.citationA fucoidan from sea cucumber Pearsonothuria graeffei with well-repeated structure alleviated gut microbiota dysbiosis and metabolic syndromes in HFD-fed mice, S. Li, J. Li, G. Mao, T. Wu, Y. Hu, X. Ye, D. Tian, R. J. Linhardt, S. Chen, Food & Function, 9, 5371-5380, 2018.
dc.descriptionFood & Function, 9, 5371-5380
dc.descriptionNote : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
dc.description.abstractA high-fat diet (HFD) has been a major contributor to increasing morbidity caused by metabolic syndromes. Functional foods from natural sources are potential choices for addressing metabolic diseases because they provide many health benefits with a low level of adverse side effects. In our former reports, fucoidan from Pearsonothuria graeffei (fuc-Pg), a type of sulfated polysaccharides with a repeating structure, was shown to be a potential functional food ingredient. In this work, we investigated the effects of fuc-Pg on gut microbiota dysbiosis and metabolic syndromes caused by HFD. Our results indicated that fuc-Pg could reduce weight gains, alleviate hyperlipidemia, and protect the liver from steatosis in HFD-fed mice. Meanwhile, fuc-Pg decreases serum inflammatory cytokines and reduces macrophages infiltrating into adipose tissue. The gut microbiota dysbiosis caused by HFD was alleviated by administration of fuc-Pg, mainly working in the colon. Fuc-Pg increased abundances of Bacteroidetes and Actinobacteria while decreased Firmicutes and Proteobacteria. Our results indicated that fuc-Pg could be a functional food for gut microbiota dysbiosis and metabolic syndromes.
dc.relation.ispartofThe Linhardt Research Labs Online Collection
dc.relation.ispartofRensselaer Polytechnic Institute, Troy, NY
dc.subjectChemistry and chemical biology
dc.subjectChemical and biological engineering
dc.subjectBiomedical engineering
dc.titleA fucoidan from sea cucumber Pearsonothuria graeffei with well-repeated structure alleviated gut microbiota dysbiosis and metabolic syndromes in HFD-fed mice
dc.rights.holderIn Copyright : this Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s).
dc.relation.departmentThe Linhardt Research Labs.
dc.relation.departmentThe Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)

Files in this item


There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record