Show simple item record

dc.contributor.authorXie, Shaoshuai
dc.contributor.authorGuan, Yudong
dc.contributor.authorZhu, Peipei
dc.contributor.authorLi, Fei
dc.contributor.authorYu, Mengqi
dc.contributor.authorLinhardt, Robert J.
dc.contributor.authorChi, Lianli
dc.contributor.authorJin, Lan
dc.date2018
dc.date.accessioned2022-06-27T15:51:57Z
dc.date.available2022-06-27T15:51:57Z
dc.date.issued2018-10-01
dc.identifier.citationPreparation of low molecular weight heparins through nitrous acid degradation from bovine and ovine heparins, S. Xie, Y. Guan, P. Zhu, F. Li, M. Yu, R. J. Linhardt, L. Chi, L. Jin, Carbohydrate Polymers, 197, 83-91, 2018.
dc.identifier.issn1448617
dc.identifier.urihttps://doi.org/10.1016/j.carbpol.2018.05.070
dc.identifier.urihttps://hdl.handle.net/20.500.13015/5588
dc.descriptionCarbohydrate Polymers, 197, 83-91
dc.descriptionNote : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
dc.description.abstractLow molecular weight heparins (LMWHs) are important anticoagulant drugs. Nitrous acid degradation is a major approach to produce LMWHs, such as dalteparin. Due to the foreseeable shortage of porcine intestinal mucosa heparin and other potential risks, expansion of other animal tissues for heparin preparation is necessary. Heparins from different tissues differ in structure and bioactivity potency, and these variations may be carried over to the LMWH products. Sophisticated analytical techniques have been applied to compare various versions of dalteparins produced from porcine intestinal, bovine lung and ovine intestinal heparins to elucidate the effects of different animal tissues starting materials and processing conditions on the properties of final dalteparin products. With adjusted depolymerization conditions, versions of dalteparins that qualify under the European Pharmacopeia (EP) specifications were manufactured using non-porcine heparins. Dissimilarities among the three interspecies animal tissue heparin-derived dalteparins regarding fine structures are also disclosed, and their origins are discussed.
dc.description.sponsorshipScience and Technology Development Plan of Shandong Province
dc.description.urihttps://login.libproxy.rpi.edu/login?url=https://doi.org/10.1016/j.carbpol.2018.05.070
dc.languageen_US
dc.language.isoENG
dc.relation.ispartofThe Linhardt Research Labs Online Collection
dc.relation.ispartofRensselaer Polytechnic Institute, Troy, NY
dc.relation.ispartofCarbohydrate Polymers
dc.relation.urihttps://harc.rpi.edu/
dc.subjectBiology
dc.subjectChemistry and chemical biology
dc.subjectChemical and biological engineering
dc.subjectBiomedical engineering
dc.titlePreparation of low molecular weight heparins through nitrous acid degradation from bovine and ovine heparins
dc.typeArticle
dcterms.accessRightshttps://login.libproxy.rpi.edu/login?url=https://doi.org/10.1016/j.carbpol.2018.05.070
dcterms.isPartOfJournal
dcterms.isVersionOfhttps://doi.org/10.1016/j.carbpol.2018.05.070
dc.rights.holderIn Copyright : this Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). https://rightsstatements.org/page/InC/1.0/
dc.creator.identifierhttps://orcid.org/0000-0003-2219-5833
dc.relation.departmentThe Linhardt Research Labs.
dc.relation.departmentThe Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)
rpi.description.pages83-91
rpi.description.volume197


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record