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dc.contributor.authorZhang, Xing
dc.contributor.authorXia, Ke
dc.contributor.authorLin, Lei
dc.contributor.authorZhang, Fuming
dc.contributor.authorYu, Yanlei
dc.contributor.authorAnge, St Kalib
dc.contributor.authorHan, Xiaorui
dc.contributor.authorEdsinger, Eric
dc.contributor.authorSohn, Joel
dc.contributor.authorLinhardt, Robert J.
dc.identifier.citationStructural and functional components of the skate sensory organ ampullae of Lorenzini, X. Zhang, K. Xia, L. Lin, F. Zhang, Y. Yu, K. St.Ange, X. Han, E. Edsinger, J. J. Sohn, R. J. Linhardt, ACS Chemical Biology, 13, 1677–1685, 2018.
dc.descriptionACS Chemical Biology, 13, 1677–1685
dc.descriptionNote : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
dc.description.abstractThe skate, a cartilaginous fish related to sharks and rays, possesses a unique electrosensitive sensory organ known as the ampullae of Lorenzini (AoL). This organ is responsible for the detection of weak electric field changes caused by the muscle contractions of their prey. While keratan sulfate (KS) is believed to be a component of a jelly that fills this sensory organ and has been credited with its high proton conductivity, modern analytical methods have not been applied to its characterization. Surprisingly, total glycosaminoglycan (GAG) analysis demonstrates that the KS from skate jelly is extraordinarily pure, containing no other GAGs. This KS had a molecular weight of 20 to 30 kDa, consisting primarily of N-linked KS comprised mostly of a monosulfated disaccharide repeating unit, →3) Gal (1→4) GlcNAc6S (1→. Proteomic analysis of AoL jelly suggests that transferrin, keratin, and mucin serve as KS core proteins. Actin and tropomyosin are responsible for assembling the macrostructure of the jelly, and parvalbumin α-like protein and calreticulin regulate calcium and potassium channels involved in the transduction of the electrical signal, once conducted down the AoL by the jelly, serving as the molecular basis for electroreception.
dc.description.sponsorshipNational Institutes of Health
dc.relation.ispartofThe Linhardt Research Labs Online Collection
dc.relation.ispartofRensselaer Polytechnic Institute, Troy, NY
dc.relation.ispartofACS Chemical Biology
dc.subjectChemistry and chemical biology
dc.subjectChemical and biological engineering
dc.subjectBiomedical engineering
dc.titleStructural and functional components of the skate sensory organ ampullae of Lorenzini
dc.rights.holderIn Copyright : this Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s).
dc.relation.departmentThe Linhardt Research Labs.
dc.relation.departmentThe Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)

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