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    Structure and conformation of α-glucan extracted from Agaricus blazei Murill by high-speed shearing homogenization

    Author
    Zhang, Anqiang; Deng, Jiaying; Liu, Xiaoqing; He, Pengfei; He, Liang; Zhang, Fuming; Linhardt, Robert J.; Sun, Peilong
    ORCID
    https://orcid.org/0000-0003-2219-5833
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    Other Contributors
    Date Issued
    2018-07-01
    Subject
    Biology; Chemistry and chemical biology; Chemical and biological engineering; Biomedical engineering
    Degree
    Terms of Use
    In Copyright : this Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). https://rightsstatements.org/page/InC/1.0/;
    Full Citation
    Structure and conformation of α-glucan extracted from Agaricus blazei Murill by high-speed shearing homogenization, A. Zhang, J. Deng, X. Liu, P. He, L. He, F. Zhang, R.J. Linhardt, P. Sun, International Journal of Biological Macromolecules, 113, 558–564, 2018.
    Metadata
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    URI
    https://doi.org/10.1016/j.ijbiomac.2018.02.151; https://hdl.handle.net/20.500.13015/5595
    Abstract
    Agaricus blazei Murill is an edible and medicinal mushroom favored in many countries, by virtue of both its delicious taste and its potential health benefits such as its purported anticancer activity. A neutral α-glucan (ABM40-1) with a carbohydrate content of 96% was purified from the high-speed shearing homogenization extracts of A. Blazei Murill by ethanol precipitation and column chromatography. Methylation analysis along with nuclear magnetic resonance spectroscopy revealed that ABM40-1 was an α-(1 → 4)-d-glucopyranan with O-6 position occasionally occupied with α-Glcp-(1 → or α-Glcp-(1 → 6)-β-Glcp-(1 → side chains. A weight-average molecular weight of 7.34 × 106 Da was determined for ABM40-1 and its chain in solution was revealed as a compact sphere by size exclusion chromatography (SEC) coupled with a laser light scattering. This spherical conformation was also further confirmed by Congo red test and using atom force microscopy. These results suggest it would be worthwhile to further study the potential bioactivities of ABM40-1.;
    Description
    International Journal of Biological Macromolecules, 113, 558–564; Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
    Department
    The Linhardt Research Labs.; The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS);
    Relationships
    The Linhardt Research Labs Online Collection; Rensselaer Polytechnic Institute, Troy, NY; International Journal of Biological Macromolecules; https://harc.rpi.edu/;
    Access
    https://login.libproxy.rpi.edu/login?url=https://doi.org/10.1016/j.ijbiomac.2018.02.151;
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