Show simple item record

dc.contributor.authorDumont, C.M.
dc.contributor.authorPiselli, J.
dc.contributor.authorKazi, N.
dc.contributor.authorBowman, E.
dc.contributor.authorLi, G.
dc.contributor.authorLinhardt, Robert J.
dc.contributor.authorTemple, S.
dc.contributor.authorDai, G.
dc.contributor.authorThompson, D.M.
dc.date2017
dc.date.accessioned2022-06-27T16:01:10Z
dc.date.available2022-06-27T16:01:10Z
dc.date.issued2017
dc.identifier.citationFactors released from endothelial cells exposed to flow impact adhesion, proliferation, and fate choice in the adult NSC lineage, C. M. Dumont, J. Piselli, N. Kazi, E. Bowman, G. Li, R. J. Linhardt, S. Temple, G. Dai, D. M. Thompson, Stem Cells and Development, 26, 1199-1213, 2017.
dc.identifier.urihttps://doi.org/10.1089/scd.2016.0350
dc.identifier.urihttps://hdl.handle.net/20.500.13015/5619
dc.descriptionStem Cells and Development, 26, 1199-1213
dc.descriptionNote : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
dc.description.abstractThe microvasculature within the neural stem cell (NSC) niche promotes self-renewal and regulates lineage progression. Previous work identified endothelial-produced soluble factors as key regulators of neural progenitor cell (NPC) fate and proliferation; however, endothelial cells (ECs) are sensitive to local hemodynamics, and the effect of this key physiological process has not been defined. In this study, we evaluated adult mouse NPC response to soluble factors isolated from static or dynamic (flow) EC cultures. Endothelial factors generated under dynamic conditions significantly increased neuronal differentiation, while those released under static conditions stimulated oligodendrocyte differentiation. Flow increases EC release of neurogenic factors and of heparin sulfate glycosaminoglycans that increase their bioactivity, likely underlying the enhanced neuronal differentiation. Additionally, endothelial factors, especially from static conditions, promoted adherent growth. Together, our data suggest that blood flow may impact proliferation, adhesion, and the neuron-glial fate choice of adult NPCs, with implications for diseases and aging that reduce flow.
dc.description.urihttps://login.libproxy.rpi.edu/login?url=https://doi.org/10.1089/scd.2016.0350
dc.languageen_US
dc.language.isoENG
dc.relation.ispartofThe Linhardt Research Labs Online Collection
dc.relation.ispartofRensselaer Polytechnic Institute, Troy, NY
dc.relation.urihttps://harc.rpi.edu/
dc.subjectBiology
dc.subjectChemistry and chemical biology
dc.subjectChemical and biological engineering
dc.subjectBiomedical engineering
dc.titleFactors released from endothelial cells exposed to flow impact adhesion, proliferation, and fate choice in the adult NSC lineage
dc.typeArticle
dcterms.accessRightshttps://login.libproxy.rpi.edu/login?url=https://doi.org/10.1089/scd.2016.0350
dcterms.isVersionOfhttps://doi.org/10.1089/scd.2016.0350
dc.rights.holderIn Copyright : this Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). https://rightsstatements.org/page/InC/1.0/
dc.creator.identifierhttps://orcid.org/0000-0003-2219-5833
dc.relation.departmentThe Linhardt Research Labs.
dc.relation.departmentThe Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record