Author
Li, Shan; Li, Junhui; Zhi, Zijian; Wei, Chaoyang; Wang, Wenjun; Ding, Tian; Ye, Xingqian; Hu, Yaqin; Linhardt, Robert J.; Chen, Shiguo
Other Contributors
Date Issued
2017-10-01
Subject
Biology; Chemistry and chemical biology; Chemical and biological engineering; Biomedical engineering
Degree
Terms of Use
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Full Citation
Macromolecular properties and hypolipidemic effects of four sulfated polysaccharides from sea cucumbers, S. Li, J. Li, Z. Zhi, C. Wei, W. Wang, T. Ding, X. Ye, Y. Hu, R. J. Linhardt, S. Chen, Carbohydrate Polymers, 173, 330–337, 2017.
Abstract
The present study investigates the relationship between the high-order structure and hypolipidemic activity of four well-defined sulfated fucans from sea cucumber. The chain conformation, determined by a combination of AFM and SEC-MALLS-RI, indicate that fucosylated chondroitin sulfate (fCS) from Pearsonothuria graeffei (fCS-Pg) and Isostichopus badionotus (fCS-Ib), and fucoidan from P.graeffei (fuc-Pg) were assigned as a random coil conformation with polysaccharide chain outstretched, while I. badionotus (fuc-Ib) was assigned as a spherical conformation and exhibited high viscosity. Fuc-Pg and fuc-Ib with higher molecular weights had a greater impact in inhibiting pancreatic lipase activity in vitro. However, fCS-Pg, fCS-Ib and fuc-Pg with random linear conformation exhibited excellent hypolipidemic activity in Sprague-Dawley rats (SD rats) fed on high-fat diet (HFD), whereas fuc-Ib showed only a modest effect. Our results indicate that structural characteristics, including side branch and sulfation pattern can affect the chain conformation of polysaccharides, which determine their physicochemical properties and hypolipidemic activity.;
Description
Carbohydrate Polymers, 173, 330–337; Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
Department
The Linhardt Research Labs.; The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS);
Relationships
The Linhardt Research Labs Online Collection; Rensselaer Polytechnic Institute, Troy, NY; Carbohydrate Polymers; https://harc.rpi.edu/;
Access
https://login.libproxy.rpi.edu/login?url=https://doi.org/10.1016/j.carbpol.2017.05.063;
